Michael Mullan Alzheimers Research


The Roskamp Institute is devoted to understanding causes of and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. Based in Sarasota, Florida, the Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease.

Headed by Dr. Michael Mullan, the institute employs experienced and interdisciplinary scientists and technicians and houses state-of-the-art research labs and equipment to conduct scientific research. The quality of research performed at the institute reflects its motto: “Better science. Real discovery.”


Michael Mullan is a biomedical researcher of the β-amyloid protein and its relation to Alzheimer’s disease. Mullan’s Alzheimer research is well known among Biomedical Community. Dr. Mullan Alzheimer research work resulted in identifying the most widely known Swiss Mutation that is present in familial form. Transgenic Animal for Alzheimer Disease uses Swiss Mutation.

Dr. Mullan is currently the director[1] of the Roskamp Institute in Sarasota, Florida. Under Dr. Mullan’s guidelines the institute is carrying out cutting edge research in Alzheimer’s, Traumatic Brain Research, Gulf War Illness and other neuropsychiatric disorder.


Please visit websites to learn about Dr. Mullan Alzheimer’s Research Website:



Recent Posts

Treating Alzheimer’s disease: A New Chemical Approach

From the University of Liverpool and Callaghan Innovation in New Zealand comes a

study that local scientists have been developing; a new kind of chemical approach that will

harness the natural ability of complex sugars in the treatment Alzheimer’s disease.


The team of scientists produced a new library of sugars called heparan sulphates, which are known to control the proteins in the brain that cause memory loss.  This research has discovered  a way of efficiently producing heparan sulphates chemically within a lab, a major step in Alzheimer’s research because heparan sulphates have been found to  block an enzyme in the brain that creates small proteins.  The proteins this enzyme creates are are amyloid proteins, which work as building blocks to create plaque that causes the characteristic memory loss with the progression of Alzheimer’s.  Professor Jerry Turnbull from the University Institute of Integrative Biology remarked that the enzyme they are targeting with their chemically produced sugars is BACE, the enzyme responsible for the creation of amyloid protein.  BACE had proved a difficult enzyme to isolate and block despite many efforts by drug companies, but the ability to mass-produce the heparan sulphates has allowed scientists to continue and further their research of the enzyme.  Using their new chemical approach, research will continue on to test the heparan compounds which work most effectively to block the enzyme, and give off the least amount of side effects.  The creation of lab techniques that allow the production of heparan in mass and the resultant research on the sugar’s BACE enzyme blocking abilities will allow continued research, and hopefully new medications targeted at treating and slowing the progression of Alzheimer’s.


1) Ralf Schwörer, Olga V. Zubkova, Jeremy E. Turnbull, Peter C. Tyler. Synthesis of a Targeted Library of Heparan Sulfate Hexa-to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease. Chemistry – A European Journal, 2013; 19 (21): 6817 DOI: 10.1002/chem.201204519


2) University of Liverpool (2013, May 29). New chemical approach to treat Alzheimer’s.ScienceDaily. Retrieved June 4, 2013, from http://www.sciencedaily.com /releases/2013/05/


By: Lauren Horne

The Roskamp Institute is a 501(c)3 research facility dedicated to translating the efforts of its qualified research staff into real-world results for those suffering from neurological diseases. To learn more about our programs and to get information about donating, visit www.rfdn.org.

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  3. Alzheimer’s in Mice: Drug-reversible? Comments Off
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  15. The Effects of Parkinson’s disease Mutations Reversed within Cells Comments Off
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  18. Amino Acids Improve Sleep in Mice with Traumatic Brain Injury Comments Off
  19. Controlling length of mitochondria may cure Alzheimer’s diseases Comments Off
  20. Biomarker Could Aid in Revealing Alzheimer’s Early Comments Off
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  22. Dr. Michael Mullan Article Published in Herald Tribune: Dr. Michael Mullan: Volunteer to help fight Alzheimer’s Comments Off
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  24. Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer’s Abeta Peptide. Comments Off
  25. Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer’s disease. Comments Off
  26. Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier. Bachmeier C, Mullan M, Paris D. Comments Off
  27. Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer’s disease. Comments Off
  28. Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier. Comments Off
  29. Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Comments Off
  30. Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier. Comments Off
  31. Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid. Comments Off
  32. Flavonoids lower Alzheimer’s Aβ production via an NFκB dependent mechanism. Comments Off
  33. Roskamp Institute in Sarasota, Florida, have shown that an anatabine compound supplied by Rock Creek has beneficial effects on memory and learning in animal models of Alzheimer’s Disease. Michael Mullan, MD, Ph.D., CEO of the Roskamp Institute and his colleague, Dr. Daniel Paris, published these findings in October, 2011 in the European Journal of Pharmacology Comments Off
  34. Mike Mullan Alzheimer Researcher Comments on: Nicotine May Help Combat Memory Loss study by Dr. Newhouse Comments Off
  35. Identification of Plasma Biomarkers of TBI Outcome Using Proteomic Approaches in an APOE Mouse Model. Comments Off
  36. Anatabine lowers Alzheimer’s Aβ production in vitro and in vivo Comments Off
  37. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer’s disease. Comments Off
  38. Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons. Comments Off
  39. Proteomic CNS profile of delayed cognitive impairment in mice exposed to gulf war agents. Comments Off
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  41. Sarasota’s Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes Comments Off
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  46. Roskamp Institute finds one of the genetic causes for Tourettes syndrome Comments Off
  47. Sarasota’s Roskamp Institute Welcomes U.S. Senator Bill Nelson Comments Off
  48. Dr. Mullan’s Alzheimer Research Offers Invaluable Insights On The Disease Comments Off
  49. Dr. Mullan’s Alzheimer Research Identified Various Genetic Variations Comments Off
  50. Family History of Alzheimer’s disease – what does it mean? Comments Off
  51. ß-amyloid exchage in the blood-brain barrier Comments Off
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  53. Alzheimer’s disease drug developed at Roskamp Institute approved for key clinical trial funding in Europe Comments Off
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  55. Research Highlights The Direct Causes Related To The Disease Comments Off
  56. Dr. Mullan’s Alzheimer Research Involved Studying Brain Proteins Comments Off
  57. Roskamp Institute researchers show that some antibodies but, not others may be helpful in removing the Alzheimer amyloid from the brain of Alzheimer’s sufferers. Comments Off
  58. Mullan Alzheimer Research Institute Roskamp Institute aids high school students in genetic research Comments Off
  59. The Roskamp Institute investigates the role of anatabine in lowering Alzheimer’s Abeta levels. Comments Off
  60. Alzheimer Research Institute Headed By Dr. Michael Mullan Featured in the Sarasota Herald Tribune : Roskamp Institute research could help veterans Comments Off
  61. Dr. Mullan Alzheimer Presentation at Pines of Sarasota Comments Off
  62. Roskamp Institute Celebrated Veterans Day with a seminar by Alzheimer Researcher Dr. Michael Mullan Comments Off
  63. Alzheimer Expert Dr. Mullan’s comments on CD40L induces Abeta production via signaling by the granulocyte macrophage colony stimulating factor (GM-CSF) Comments Off
  64. Alzheimer Researcher Dr. Michael Mullans Note on Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide. Comments Off
  65. Effect of NSAIDS on cognitive ability of Alzheimer’s Patient — Comment by Alzheimer Researcher Mullan Comments Off
  66. Dr. Mullan’s Alzheimer Research Notes on NSAIDS and their effect on Alzheimers disease Comments Off
  67. Roskamp Institute Gulf War Illness research program Comments Off
  68. Event: Journal Club “Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1–neuregulin cascade” Comments Off
  69. Event: Journal Club “The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease” Comments Off
  70. News:Nomination for Business/Education Partnership Award through the School District of Manatee County’s ePIE program Comments Off
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  76. Event Journal Club:Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice Comments Off
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  87. Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer’s Abeta Peptide Comments Off
  88. Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer’s disease Comments Off
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  100. Characteristics of thein VitroVasoactivity of β-Amyloid Peptides Comments Off
  101. Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer’s disease Comments Off
  102. Cross Validation of the Montreal Cognitive Assessment in Community Dwelling Older Adults Residing in the Southeastern US Comments Off
  103. Volunteers for early detection of cognitive decline in older adults Comments Off
  104. Roskamp Institute hosted a town hall meeting for the Alzheimer’s Association. Comments Off
  105. Roskamp Institute Scientist Awarded a grant from the Alzheimers Association to investigate a novel therapeutic agent for the treatment of Alzheimer’s Disease. Comments Off
  106. Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer’s Disease. Comments Off
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  109. Local Researchers at Roskamp Institute to Test Investigational Gammaglobulin Treatment for Alzheimer’s Disease Comments Off
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  126. Genetic manipulation of CD40L reduces Tau phosphorylation Comments Off
  127. The granulocyte macrophage-colony stimulating factor (GM-CSF) regulates amyloid production Comments Off
  128. Potent antiangiogenic motif in amyloid beta Comments Off
  129. CD40L induces Abeta production via signaling by the granulocyte macrophage colony stimulating factor (GM-CSF) Comments Off
  130. Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide Comments Off
  131. Effect of NSAIDS on cognitive ability of Alzheimer’s Patients Comments Off
  132. NSAIDS and their effect on Alzheimers disease Comments Off
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  142. Roskamp Institute Alzheimer’s Research Validated by Independent Japanese Study Comments Off
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  144. Roskamp Institute Studying Potential Usefulness of Beta-amyloid in Treating Alzheimer’s Comments Off
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  150. Sarasota’s Roskamp Institute Welcomes U.S. Senator Bill Nelson Comments Off
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  178. The Roskamp Institute is Participating in a New Phase III MS Study Comments Off
  179. Michael Mullan Featured in Another Story Comments Off
  180. Roskamp’s Michael Mullan Interviewed by St. Petersburg Times Comments Off
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  183. Roskamp Institute Announces New Class Of Drugs That Can Impact Alzheimer’s Disease Comments Off