Handling Unstructured Data in Biological Research and Clinical Trials

Venkatarajan S. Mathura Complex information that are available in a crude format make computational modeling and processing a difficult objective in Biological and Health care research. Protocol revisions, process flexibility, user adoptability should be considered in mind to develop an user friendly information management solution. There is a great need to integrate data from several […]

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Tech Tips:

By Our Mass Spectrometry Guru Jon Reed This will be the first in an ongoing series of technical tips for those interested in biochemistry and mass spectrometry.  Anyone involved with these fields knows there can be considerable headache and heartache that goes hand-in-hand with even the simplest of experiments.  Along the way, I’ve picked up […]

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Roskamp Institute-LECOM collaboration

Dr. Corbin Bachmeier of the Roskamp Institute is currently investigating the drug efflux transport interactions of various antidepressants in collaboration with Dr. Gary Levin of the Lake Erie College of Osteopathic Medicine (LECOM) in Bradenton, FL.  Dr. Bachmeier and Dr. Levin are co-investigators of a grant, provided by Wyeth Pharmaceuticals, which examines the interactions of […]

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High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer’s disease patients

Alzheimer’s disease is clinically characterized by progressive cognitive decline accompanied by the presence of amyloid plaques and neurofibrillary tangles in the brain of Alzheimer’s patients. A small protein fragment beta-amyloid (Abeta) with 42 amino acids is shown to deposit earlier in the disease process than the slightly shorter form (40 amino acid fragment).  Both species […]

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Journal Club: The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

JC Nowell Ganey will present “The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia” on Thursday (29th April 2010) at 4:00pm in Roskamp Institute. You can find the article in the following link. The Roskamp Institute provides a full range of services for individuals with Alzheimer’s disease including diagnostic work-up […]

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Alzheimer’s Disease Anti-Inflammatory Prevention Trial

The Roskamp Institute Memory Center is actively following a large number of subjects who participated in the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT). Although earlier detection and the development of disease modifying treatment continues to be a primary focus of research and several potential compounds are under clinical trial, more prevention studies are needed. The […]

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Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

A methodology is described for use of a 16-hole circular platform task to test spatial memory in mice. Both bright light and a fan were used to motivate mice to escape the platform surface through a single hole containing an attached escape box. For each daily trial, three correlated measures (escape latency, number of errors, […]

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