Can an Epilepsy Drug Be the Answer to Preventing Alzheimer’s Dementia?

Doctor shows the patient how to use daily dose pills

An exciting research study has concluded at Johns Hopkins University and the results could be great news for the millions of patients who suffer from Alzheimer’s dementia. Epilepsy is a common neurological disorder that affects more than 50 million people in the world. A new drug, antiepileptic levetiracetam, has proved to be successful in reducing […]

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Newly Discovered Control Switch Key to Saving Cells from Untimely Death

Cell stress magnified by chronic disease All of us undergo stress, but those dealing with chronic illnesses such as cancers, diabetes, inflammatory diseases, and neurological degenerative diseases such as Parkinson’s and Alzheimer’s are at an increased level of danger due to a naturally occurring cell stress control mechanism. However, according to a newly released study, […]

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Treating Alzheimer’s disease: A New Chemical Approach

From the University of Liverpool and Callaghan Innovation in New Zealand comes a study that local scientists have been developing; a new kind of chemical approach that will harness the natural ability of complex sugars in the treatment Alzheimer’s disease.   The team of scientists produced a new library of sugars called heparan sulphates, which […]

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Alzheimer’s disease: Molecular Chain Reaction Found?

Researchers at Lund University in Sweden headed by Professor Singerup Linse and Erik Helistrand have recently identified a molecular mechanism behind the crucial step in Alzheimer’s that leads to the death of brain cells.   The neurological disease is associated, as a general statement, with memory loss and changes in personality.  The research at Lund […]

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Children of Long-lived Parents: Less Risk of Cancer?

  A recently completed study at the University of Exeter showed that people with long-lived parents had a twenty-four percent decreased chance of getting cancer.  The parameters of ‘long-lived’ defined as mothers who lived past ninety-one years and fathers who lived past eighty-seven years. A side study posted from the National Institute for Health and […]

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Alzheimer’s in Mice: Drug-reversible?

Within the journal Science, University of Pittsburgh Graduate School of Public Health scientists confirm that a study performed on mouse models of Alzheimer’s disease had significantly improved brain function and memory capabilities after being treated with an anti-cancer drug. The cancer drug, known as bexarotene, has previously been studied and used for the treatment cutaneous […]

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Triumphs in Genetic Sequencing of Human Diseases

  At Queen Mary University in London, researchers have conducted the largest study of genetic sequencing of human diseases known to date, identifying the genetic basis of six different diseases: autoimmune thyroid disease, celiac disease, Crohn’s disease, psoriasis, multiple sclerosis, and type 1 diabetes. According to the study, though the exact causes of these diseases […]

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Linked: Can Skin Cancer Lower Risk of Alzheimer’s disease?

A study published in the May 2013 online issue of Neurology follows researchers in Minneapolis who performed a study where 1,102 participants, of an averaged an age of 79, were followed for the span of 3.7 years and tested to see if ever they developed dementia. At the start of the study, 109 of the […]

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A Promising New Alzheimer’s Drug Stops Memory Loss

According to Northwestern Medicine Research, new experimental molecules have great promise in targeting enzymes in the brain that prevent memory loss in Alzheimer’s disease.  Developed in D. Martin Watterson’s laboratory, the molecules halted memory loss and were able to fix damaged communication between brain cells in mice. Researchers identified and targeted a key enzyme: a […]

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Antibodies Effectively Treat Alzheimer’s-like Disease

Drs. David Holtzman and Mac Diamond of the Washington University School of Medicine recently published research in Neuron that outlined the process of studying mice for potential tau protein tangle treatment avenues. Tau is a toxic component of Alzheimer’s and other neurodegenerative diseases, due to the protein’s tendency to amass in tangles.  The aggregates, called […]

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ACE Inhibitors and Alzheimer’s Prevention

Cedars-Sinai scientists published a study in Journal of Clinical Investigation that suggests ACE inhibitors, in the right context and at the right time, can be a good thing.   Many people with high blood pressure take ACE inhibitors, medication meant to widen blood vessels by limiting activity of ACE (angiotensin-converting enzyme), a naturally occurring protein. […]

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Investigational Therapy Focuses on Slowing Progression in Mild and Moderate

Researchers at Houston Methodist’s Nantz National Alzheimer Center are studying an investigational drug to slow brain cell deterioration in patients with mild to moderate Alzheimer’s disease. T-817MA focuses on preventing brain cell loss and slowing disease progression, where current treatment options like Donepezil, Rivastigmine, and Memantine only treat the symptoms.  The scientists want to know […]

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A Vicious Cycle of Alzheimer’s and Diabetic Hypoglicemia?

A study conducted recently at the Univeraity of California- San Francisco published online in  JAMA Internal Medicine. The research was focused in on finding a close link between diabetes and dementia. According to the journal, diabetic patients with low blood sugar may have an increased risk of developing dementia, and patients with dementia or other […]

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A New Drug Reverses Lost Brain Connections in Alzheimer’s Disease

Researchers at Sanford-Burnham Medical Research Institute have developed the first experimental drug named NitroMemantine that boosts brain synapses lost to Alzheimer’s disease. The medication combines two FDA-approved drugs to stop destructive cascades within the brain, which destroys the connections between neurons and ultimatly leads to memory loss and a decline in cognition. Dr. Stuart A. […]

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Green Tea May Help Prevent Alzheimer’s Disease

Researchers at the Michigan Alzheimer’s Disease Center discovered that flavored ECGC, or epigallocatechi-3-gallate, found in green tea could bind to the toxic protein beta-amyloid and prevent its build-up. When ECGC binds to the protein, it is able to change beta-amyloid’s properties. Dr. Mi Hee Lim, lead researcher of the study, found that ECGC bonded to […]

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Alzheimer’s Disease Progression Halted Due to Increased Protein Expression

A recent report from researchers at the Massachusetts General Hospital which identifies a protein that aids the immune system in the removal of A-beta protein from the brain, could lead to new treatments of Alzheimer’s disease. According to cocorresponding author of the report, Dr. Joseph Eli Khoury of the Center for Immunology and Inflammatory Diseases […]

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Stem Cells Used to Grow New Neurons, Brain Repair Circuit Identified

Researchers at Duke University have identified a new type of neuron within the adult brain capable of directing stem cells to make new neurons. The experiments are preliminary, but the hope is that the brain one day could be healing itself from within. Chay Kuo, M.D, Ph.D., an assistant professor of cell biology, neurobiology, and […]

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The Effects of Parkinson’s disease Mutations Reversed within Cells

A recent study from University of California, San Francisco scientists found that a chemical in anti-wrinkle cream could effectively prevent the death of nerve cells that had been damaged by mutations which cause an inherited form of Parkinson’s disease. According to the study’s senior scientist, UCSF chemist Kevan Shokat, PhD; the study targeted an enzyme […]

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A New Study Shows Small-molecule Drug through Blood-Brain Barrier

Mayo clinic researchers demonstrated within a mouse model that a synthetic peptide carrier works to deliver brain cancer chemotherapy drugs, as well as neurological medications. Neuroscientist Gobinda Sarkar, Ph.D, of the Mayo Clinic and corresponding author of the study discussed that they were able to transport eight different molecules, and much less disruptively through the […]

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Antidepressant May Slow Progression of Alzheimer’s Disease

According to research by the Washington University School of Medicine, published in Science Translational Medicine, a common antidepressant can reduce the production of brain plaques. Brain plaques correlate closely with memory problems and other cognitive impairments caused by Alzheimer’s disease.  Stopping plaque buildup is believed to help halt the mental decline of Alzheimer’s patients.  Scientists […]

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Amino Acids Improve Sleep in Mice with Traumatic Brain Injury

Amino Acids Improve Sleep in Mice with Traumatic Brain Injury  A study by Oregon Health and Science University, published in Science Translational Medicine, discovered a way to fix sleep disturbances in mice suffering from traumatic brain injury.  These results are important, because people commonly experience long-term and severe sleep and wakefulness issues after suffering concussions, […]

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Controlling length of mitochondria may cure Alzheimer’s diseases

In a recent study, scientists at the Queensland Brain Institute (QBI) at the University of Queensland and Harvard University have found in their research that the length of the mitochondria may be related to Alzheimer’s treatment. Mitochondria are organelles that metabolize energy for the all the cells. The scientists found in cases where there were […]

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Biomarker Could Aid in Revealing Alzheimer’s Early

A new study recently published in the journal Annals of Neurology discussed the identification of what could be the earliest-known biomarker that is associated with the risk of developing Alzheimer’s disease. Results of the study showed that the biomarker was present within Cerebral Spinal Fluid (CSF) for at least a decade before any signs of […]

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Michael Mullan: Brain Fitness Programs – a scam ?

Perform a web search on “brain scam” and you will find several articles questioning the veracity of claims made with respect to brain fitness or brain exercise programs. Are these programs a scam? One thing is clear, they appear to be rapidly increasing in popularity – all the way from self help books and DVDs […]

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Alzheimer Researcher Dr. Michael Mullans Note on Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide.

A study entitled “Potent anti-angiogenic motifs within the Alzheimer’s β-amyloid peptide” was published in the January 2008 issue of the journal Amyloid. Building on previous work by Dr. Michael Mullan showing that the Alzheimer’s Aβ peptide is able to prevent blood vessel growth and inhibit tumor growth, Dr. Michael Mullan and other Roskamp Institute scientists […]

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Effect of NSAIDS on cognitive ability of Alzheimer’s Patient — Comment by Alzheimer Researcher Mullan

Medications that reduce inflammation known as non-steroidal anti-inflammatory drugs (NSAIDS) do not improve thinking abilities in normal seniors.  These findings from the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) were published this month in Archives of Neurology. The Roskamp Institute Memory Clinic in Tampa was one of a handful of centers across the United States that […]

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Event: Journal Club “Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1–neuregulin cascade”

Laila Abdullah will be presenting the paper on Friday (7/2/2010) at Roskamp Institute. Title:Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1–neuregulin cascade Journal: PNAS 5622–5627 | March 23, 2010 | vol. 107 | no. 12 Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter […]

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Event: Journal Club “The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease”

Nowell (Jim) Ganey will be presenting the paper on Friday (6/25/2010) at Roskamp Institute. Title:The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease. Journal : Biomaterials. 2010 Jul;31(21):5608-18. Epub 2010 Apr 28. Journal Club is held every Friday between 4 Pm-5pm. For change in […]

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News:Nomination for Business/Education Partnership Award through the School District of Manatee County’s ePIE program

The Roskamp Institute has been nominated for a Business/Education Partnership Award through the School District of Manatee County‘s ePIE program. Since 1990, this awards program recognizes businesses, organizations, and individuals who have made the commitment to work together to enhance education in the School District of Manatee County. The awards ceremony will be held in August. […]

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News:Roskamp Institute was recognized by the South East High School Technical Student association for partnering will the in a diabetes project

On Tuesday June 15th the Roskamp Institute was recognized by the South East High School  Technical Student association for partnering will the in a diabetes project.  At the Victory celebration banquet held at South East High following the TSA teams success in the State TSA finals. The Diabetes project was awarded second place in the […]

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News: FDA advisory committee unanimously recommends approval of Novartis investigational treatment FTY720 to treat relapsing remitting MS

The Roskamp Institute continues to actively recruit clinical research participants for the treatment of both Alzheimer’s disease and Multiple sclerosis. We are proud to share the following press announcement regarding a clinical trial/potential treatment that Roskamp Institute has been involved in since 2006: “FDA advisory committee unanimously recommends approval of Novartis investigational treatment FTY720 to […]

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Event: Journal Club “NF-jB activity affects learning in aversive tasks: Possible actions via modulation of the stress axis”

Scott Ferguson will be presenting the paper on Friday (6/18/2010) at Roskamp Institute. Title:NF-κB activity affects learning in aversive tasks: Possible actions via modulation of the stress axis Journal: Brain, Behavior, and Immunity doi:10.1016/j.bbi.2010.04.005 Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter account or facebook page. […]

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Event Journal Club:Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice by Rhein et al. Alex Bishop will be presenting the paper on Friday (6/11/2010) at Roskamp Institute. Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter account or facebook page. The Roskamp […]

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Event: Journal Club

Benoit Mouzon will be presenting “Blood-brain barrier breakdown and repair by Src after thrombin-induced injury” by Liu et al. The journal club will start at 4:00pm on Friday (may 28th 2010) in the auditorium at Roskamp Institute. The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. […]

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Announcement

The Roskamp Institute Memory Center and Clinical Trials Division is pleased to announce the addition of Ms. Yahdinah Alvarez to the clinical team.  Ms. Alvarez is an experienced clinical trial coordinator with expertise in Alzheimer’s and Parkinson’s disease studies.  If you or your loved one is suffering with Alzheimer’s disease or Parkinson’s disease, please contact […]

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News:Dr Crawford will be speaking at 2nd Annual Girls S.T.E.M. Summit

2nd Annual Science, Technology, Engineering & Math (S.T.E.M.) Summit at USF  Sarasota-Manatee on Saturday,  will start at 9 AM in May 22nd. Dr Crawford will give a speech about women in science. For more information visit S.T.E.M. website. The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and […]

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Alzheimer’s beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2

By Patel NS, Mathura VS, Bachmeier C, Beaulieu-Abdelahad D, Laporte V, Weeks O, Mullan M, Paris D. Published in J Neurochem. 2010 Jan;112(1):66-76. Roskamp Institute, Sarasota, Florida, USA. npatel@scripps.edu Abstract Beta-amyloid peptides (Abeta) are the major constituents of senile plaques and cerebrovascular deposits in the brains of Alzheimer’s disease patients. We have shown previously that […]

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Do You Or Someone You Care For Suffer From Alzheimer’s Disease?

ALZHEIMER’S DISEASE A research study is being conducted in our area to evaluate an investigational medication for Alzheimer’s disease. Qualified participants may receive: – Study related medical care – Study medication – Compensation for time and travel Please call now for more info:    Dr. Andrew Keegan 941-256-8018 ext. 353 The Roskamp Institute Memory Clinic and […]

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Reduction of b-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer’s disease

By Daniel Paris*, Nowell J Ganey, Vincent Laporte, Nikunj S Patel, David Beaulieu-Abdelahad, Corbin Bachmeier, Amelia March, Ghania Ait-Ghezala, Michael J Mullan published in Journal of Neuroinflammation 2010, 7:17 Abstract Background: Ab deposits represent a neuropathological hallmark of Alzheimer’s disease (AD). Both soluble and insoluble Ab species are considered to be responsible for initiating the […]

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NEWS RELEASE:Investigational Immune Intervention Slows Brain Atrophy in Alzheimer’s Patients

Media Contact: Cheryl Rindfleisch, Roskamp Institute 941-256-8018 x356 crindfleisch@rfdn.org or Jeffree Itrich  858-622-5827 jitrich@ucsd.edu May 10, 2010 Investigational Immune Intervention Slows Brain Atrophy in Alzheimer’s Patients 18-Month Phase 2 Study is First to Show Combined Benefits of IGIV on Clinical Outcomes and Brain-Imaging Measures Phase 3 Study Now Enrolling Participants at the Roskamp Institute in […]

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Journal Club

Jeremy Frieling is presenting “Days-to-criterion as an indicator of toxicity associated with human Alzheimer amyloid- oligomers” by Gandy et al. Location: Roskamp Institute Date: May 14th 2010 Time: 4:00PM The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific […]

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FREE MEMORY SCREENING-Sarasota FL

Are you or someone you know suffering from memory loss or forgetfulness? Roskamp Institute is offering FREE MEMORY SCREENING for adults age 60 or older. For an appointment call:               Roskamp Institute 941-256-8018 ext. 349 The Roskamp Institute Memory Clinic and Clinical Trials Division provide a full range of services for individuals with Alzheimer’s disease […]

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Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer’s Abeta Peptide

By Daniel Paris • Nikunj Patel • Nowell J. Ganey • Vincent Laporte • Amita Quadros • Michael J. Mullan Int J Pept Res Ther (2010) 16:23–3.  DOI 10.1007/s10989-010-9198-8 Abstract: The inhibition of angiogenesis is regarded as a promising avenue for cancer treatment. Although some antiangiogenic compounds are in the process of development and testing, […]

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Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer’s disease

By Ait-ghezala G, Abdullah L, Volmar CH, Paris D, Luis CA, Quadros A, Mouzon B, Mullan MA, Keegan AP, Parrish J, Crawford FC, Mathura VS, Mullan MJ. Cytokine. 2008 Nov;44(2):283-7. A continuous inflammatory state is associated with Alzheimer’s disease (AD) evidenced by an increase in proinflammatory cytokines around beta-amyloid (Abeta) deposits. In addition, functional loss […]

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CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling.

By Volmar CH, Ait-Ghezala G, Frieling J, Weeks OI, Mullan MJ. Exp Cell Res. 2009 Aug 1;315(13):2265-74. CD40, a member of tumor necrosis factor receptor superfamily, and its cognate ligand CD40L are both elevated in the brain of Alzheimer’s disease (AD) patients compared to controls. We have shown that pharmacological or genetic interruption of CD40/CD40L […]

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Handling Unstructured Data in Biological Research and Clinical Trials

Venkatarajan S. Mathura Complex information that are available in a crude format make computational modeling and processing a difficult objective in Biological and Health care research. Protocol revisions, process flexibility, user adoptability should be considered in mind to develop an user friendly information management solution. There is a great need to integrate data from several […]

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Tech Tips:

By Our Mass Spectrometry Guru Jon Reed This will be the first in an ongoing series of technical tips for those interested in biochemistry and mass spectrometry.  Anyone involved with these fields knows there can be considerable headache and heartache that goes hand-in-hand with even the simplest of experiments.  Along the way, I’ve picked up […]

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Roskamp Institute-LECOM collaboration

Dr. Corbin Bachmeier of the Roskamp Institute is currently investigating the drug efflux transport interactions of various antidepressants in collaboration with Dr. Gary Levin of the Lake Erie College of Osteopathic Medicine (LECOM) in Bradenton, FL.  Dr. Bachmeier and Dr. Levin are co-investigators of a grant, provided by Wyeth Pharmaceuticals, which examines the interactions of […]

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High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer’s disease patients

Alzheimer’s disease is clinically characterized by progressive cognitive decline accompanied by the presence of amyloid plaques and neurofibrillary tangles in the brain of Alzheimer’s patients. A small protein fragment beta-amyloid (Abeta) with 42 amino acids is shown to deposit earlier in the disease process than the slightly shorter form (40 amino acid fragment).  Both species […]

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Journal Club: The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

JC Nowell Ganey will present “The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia” on Thursday (29th April 2010) at 4:00pm in Roskamp Institute. You can find the article in the following link. The Roskamp Institute provides a full range of services for individuals with Alzheimer’s disease including diagnostic work-up […]

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Alzheimer’s Disease Anti-Inflammatory Prevention Trial

The Roskamp Institute Memory Center is actively following a large number of subjects who participated in the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT). Although earlier detection and the development of disease modifying treatment continues to be a primary focus of research and several potential compounds are under clinical trial, more prevention studies are needed. The […]

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Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

A methodology is described for use of a 16-hole circular platform task to test spatial memory in mice. Both bright light and a fan were used to motivate mice to escape the platform surface through a single hole containing an attached escape box. For each daily trial, three correlated measures (escape latency, number of errors, […]

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Characteristics of thein VitroVasoactivity of β-Amyloid Peptides

Fiona Crawford1, Zhiming Suo, Chunhong Fang and Mike Mullan Roskamp Laboratories, Department of Psychiatry, 3515 East Fletcher Avenue, University of South Florida, Tampa, Florida, 33613 Abstract The β-amyloid (Aβ1–40) peptide has previously been shown to enhance phenylephrine contraction of aortic ringsin vitro.We have employed a novel observation, that Aβ peptides enhance endothelin-1 (ET-1) contraction, to […]

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Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer’s disease

Daniel Paris email, Nowell J Ganey email, Vincent Laporte email, Nikunj S Patel email, David Beaulieu-Abdelahad email, Corbin Bachmeier email, Amelia March email, Ghania Ait-Ghezala email and Michael J Mullan email The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA author email corresponding author email Journal of Neuroinflammation 2010, 7:17doi:10.1186/1742-2094-7-17 Published: 8 March 2010 […]

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Cross Validation of the Montreal Cognitive Assessment in Community Dwelling Older Adults Residing in the Southeastern US

By Cheryl A. Luis, Andrew Keegan, and Michael Mullan Int J Geriatr Psychiatry. 2009 Feb;24(2):197-201. Suitable methods of earlier detection of memory changes, before the full onset of a dementia are needed.  Methods such as imaging for abnormal protein accumulation in the brain and lumbar puncture to measure abnormal proteins in cerebral spinal fluid are […]

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Volunteers for early detection of cognitive decline in older adults

Dr. Cheryl Luis of the Roskamp Institute was awarded a New Investigator Research Grant from the Alzheimer’s Association in 2009.  She is studying the potential usefulness of a blood test in combination with a paper and pencil memory test for early detection of cognitive decline in older adults.  Additional research volunteers are needed.  If you […]

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Roskamp Institute hosted a town hall meeting for the Alzheimer’s Association.

Sarasota, FL The Roskamp Institute hosted a town hall meeting for the Alzheimer’s Association. Presented was “A Reason to Hope”, an Alzheimer’s Services and Treatment Update. The meeting was well attended by caregivers and local community leaders. Dr. Cheryl Luis, Associate Clinical Director of the Roskamp Institute Memory Center, presented some of her current research […]

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Roskamp Institute Scientist Awarded a grant from the Alzheimers Association to investigate a novel therapeutic agent for the treatment of Alzheimer’s Disease.

Sarasota, Fla. Dr. Daniel Paris, a senior scientist of the Roskamp Institute, was awarded an Investigator Initiated Research Grant Award from the Alzheimer’s Association to investigate the preclinical efficacy of a natural compound (celastrol) in a genetically engineered mouse model of Alzheimer’s disease. The brain of Alzheimer’s disease patients is characterized by the accumulation of […]

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Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer’s Disease.

Sarasota, FL The Roskamp Institute today announced that its researchers have uncovered a new link between inflammation and Alzheimer’s disease and have identified a potential target for developing novel therapeutics for intervention in this disease. The study, led by Roskamp Institute’s Pancham Bakshi, Ph.D., is detailed in the American Chemical Society’s Chemical Biology Journal, a […]

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Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program

Sarasota, FL Sarasota’s Roskamp Institute (Roskamp) today announced the first enrollment of students in its pioneering three-year Ph.D. program through which students will conduct full-time laboratory research with direct mentoring from internationally-recognized scientists. Roskamp is an Affiliated Research Centre (ARC) of the United Kingdom’s Open University (OU) and was recently granted a license from the […]

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Southeast High School’s Roskamp Institute project placed first in Florida and fifth in National Technology Students Association finals

Sarasota, FL Roskamp Institute was the focus of Southeast High Technology Student Association (TSA) team project in the Medical Technology category which was awarded fifth place in the Nation at the 31ST Annual TSA National Conference in Denver, Colorado June 28 – July 2 after wining first place in the State of Florida competition held […]

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Local Researchers at Roskamp Institute to Test Investigational Gammaglobulin Treatment for Alzheimer’s Disease

This summer, researchers from Roskamp Institute in Sarasota, FL, will begin testing an investigational approach to slowing down the progression of Alzheimer’s disease (AD) using Intravenous Immune Globulin (IGIV), also known as gammaglobulin. IGIV is currently used to treat primary immunodeficiency disorders but is not currently approved for treating AD, which is one of the […]

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World Alzheimer’s Day: Leaders Call for Early Diagnosis and Aggressive Research

Alzheimer’s disease carries an annual price tag of $148 billion dollars, not to mention the personal toll that it takes on the over 5.3 million patients and their families. More than 5.3 million Americans are living with Alzheimer’s, and every 72 seconds someone in America develops the disease. According to the Alzheimer’s Association, by mid-century […]

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Dementia in Older Women

A recent paper published in the Journal Neurology, which analyzed over 900 people, suggests that almost half of all women in their nineties are suffering from dementia. The study carried out in California is one of a few looking specifically at the rates of dementia in the very old. However, given our increased life expectancies, […]

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Alzheimer’s and Blood Pressure

The relationship between blood pressure and Alzheimer’s disease is complex. However, we do know that blood pressure raised in mid-life (hypertension) is a risk for the development of Alzheimer’s disease later on. Uncontrolled hypertension is a risk for dementia in general. In fact, stroke related dementias are primarily caused by either clotting or small bleeds […]

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What do the names of Barack Obama, Hillary Clinton, and John McCain have to do with Alzheimer’s disease?

Alzheimer’s disease is a neurodegenerative disorder (i.e., one which attacks neurons in the brain) which robs us of our memories, language, reasoning and thought. However, the clinical picture of Alzheimer’s has a very distinctive pattern which distinguishes it from other forms of dementia (dementia is a general term which simply means the loss of memory, […]

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Double Amyloid Causes Memory Loss

A recent paper (June 22nd from scientists from Harvard University and Trinity College, Dublin) has shown that the amyloid protein is most toxic to memory when it appears in a double form. The researchers extracted the amyloid protein (the small protein that has long thought to be the cause of Alzheimer’s) from the brains of […]

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First Critical Clinical Tests of the Amyloid Theory of Alzheimer’s Disease

In 1991, researchers currently at the Roskamp Institute published a paper in the highly prestigious Nature journal entitled “Early Onset Alzheimer’s Disease Caused by Mutations of the Amyloid Gene”. This and related findings were historic milestones in the understanding of the causes of Alzheimer’s disease. Today, seventeen years later, Roskamp Institute researchers are delighted to […]

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Alzheimer’s Disease Drug development

An article in the Wall Street Journal on the 18th of June 2008, encapsulates the current expectation, hope and knowledge in the field of Alzheimer’s disease research. Researchers at the Roskamp Institute (Institute) have been part of the history of the discovery of new possibilities for stopping this devastating disease. The article importantly discusses the […]

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Traumatic Brain Injury in the War Zone

An article in the New England Journal of Medicine entitled “Traumatic Brain Injury in the War Zone” details the experiences of a supply officer with a US Army Stryker Brigade after suffering a head injury in Northern Iraq in a convoy transporting Iraqi volunteers to Mosul for military training. The officer reported remembering that the […]

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ABeta as Antiangiogenic drug

Roskamp Institute has previously worked extensively on the ability of amyloid (the main protein that causes Alzheimer’s disease) to stop the growth of blood vessels. Although this is bad news in Alzheimer’s and probably contributes to the decline in cognitive function the effect has been turned to good use in other areas. The Roskamp Institute […]

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Roskamp Institute examines the cellular responses to biological warfare agents

In September of 2004, the research advisory committee on Gulf War veteran’s illnesses produced a report and recommendation on the scientific progress and understanding the complex condition known as Gulf War Syndrome. This report suggested that important contributors to Gulf War Syndrome included the nerve agent prophylaxis pill, pyridostigmine bromide, pesticide exposure and potentially anthrax […]

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Genetic manipulation of CD40L reduces Tau phosphorylation

Mainly two cerebral lesions characterized Alzheimer’s disease (AD): an extracellular deposition of the beta-amyloid peptide (Abeta) in senile plaques and an intracellular accumulation of neurofibrillary tangles (principally composed of protein tau). Besides these lesions, a continuous inflammatory state exists in the brain of AD patients. In AD brains, the tau protein becomes hyper-phosphorylated and acquires […]

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The granulocyte macrophage-colony stimulating factor (GM-CSF) regulates amyloid production

Alzheimer disease is the most common cause of dementia, afflicting 24 million people worldwide. Over time, Alzheimer’s disease gradually destroys a person’s memory and ability to learn and carry out daily activities. In addition; individuals may also experience changes in personality and behavior. Alzheimer disease is accompanied by the presence of amyloid plaques and neurofibrillary […]

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Potent antiangiogenic motif in amyloid beta

Roskamp Institute study entitled “Potent anti-angiogenic motifs within the Alzheimer’s β-amyloid peptide” was published in the January 2008 issue of the scientific journal Amyloid. Work by Dr. Michael Mullan and Dr. Daniel Paris showed that a protein central to Alzheimer’s disease pathology is also able to prevent blood vessel growth and stop tumors. In our […]

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CD40L induces Abeta production via signaling by the granulocyte macrophage colony stimulating factor (GM-CSF)

Alzheimer’s disease (AD) is the most common type of dementia in the elderly. AD is mainly characterized by the accumulation of a small molecule (known as amyloid beta (Abeta)) in the brain. Many researchers have shown that the molecule CD40L is elevated in AD patients. Roskamp Institute research group headed by Dr. Michael Mullan also […]

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Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide

A study entitled “Potent anti-angiogenic motifs within the Alzheimer’s β-amyloid peptide” was published in the January 2008 issue of the journal Amyloid. Building on previous work showing that the Alzheimer’s Aβ peptide is able to prevent blood vessel growth and inhibit tumor growth, Roskamp Institute scientists investigated particular sequences within the Alzheimer’s Aβ peptide in […]

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Effect of NSAIDS on cognitive ability of Alzheimer’s Patients

Medications that reduce inflammation known as non-steroidal anti-inflammatory drugs (NSAIDS) do not improve thinking abilities in normal seniors. These findings from the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) were published this month in Archives of Neurology. The Roskamp Institute Memory Clinic in Tampa was one of a handful of centers across the United States that […]

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NSAIDS and their effect on Alzheimers disease

Non-steroidal anti-inflammatory (NSAIDS) drugs such as Naproxen and Celecoxib do not improve cognition in at-risk older adults. These findings from the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) were published this month in Archives of Neurology.  The Roskamp Institute Memory Clinic in Tampa was one of a handful of centers across the United States that took […]

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Roskamp Institute Receives Lung Cancer Research Grant

The James & Esther King Biomedical Research Program has awarded Dr. Daniel Paris of The Roskamp Institute the Small Business Technology Transfer Grant for $100,000 to conduct a research project titled: “Treatment of Lung Adenocarcinoma and Metastasis by Anti-angiogenic Fragments of Abeta.”  The Institute has previously shown that the Abeta peptite can help inhibit the […]

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Roskamp Institute Recognized for Its Beautification Efforts

The Sarasota Herald Tribune reported yesterday that the Roskamp Institute was nominated for an Image Manatee Beautification Award. The Manatee Chamber of Commerce recognizes local businesses and organizations each quarter that contribute to the natural beauty of the area through their building design, use of drought-resistant landscaping, and other factors. Visit the Roskamp Institute website […]

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Roskamp Institute Helps Florida’s Economy

FloridaTrend.com, a site covering business issues, explained in its article “SOUTHWEST: Eye Opener” on April 1st that the Roskamp Institute’s new neuroscience doctorate program is attracting researchers to Manatee County, which is suffering from layoffs in the home construction sector. These researchers and the facility’s work help bring more money to the county’s economy. Learn […]

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Roskamp Institute Supports Moves for Greater State Funding of Biotech Research

Roskamp Institute Director Dr. Michael Mullan was one of many who represented the biotech industry at the Biotechnology Legislative Caucus yesterday to request more state funding in helping the industry thrive in the state. This is important to Florida this would help the state diversify its economy more, and many organizations within the state have […]

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Roskamp Institute Looking for Alzheimer’s Clinical Trial Participants

As reported in today’s Bradenton Herald, the Roskamp Institute is searching for clinical trial participants for two potential Alzheimer’s disease treatments. Bapineuzumab and ELND005 are being tested; both hope to successfully remove plaque from the brain which helps cause the condition. For more information please visit the Roskamp Institute Clinical Trial Division web page.

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Roskamp Institute Will Host Neuroscience Doctorate Research Program

The Roskamp Institute announced today that it will host a neuroscience doctorate research program as part of The Open University’s — of Milton Keynes, England — Affiliated Research Centre. This is the first program of this kind in Florida and will help students prepare better for researching Alzheimer’s disease and related disorders as they work […]

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Roskamp Institute Alzheimer’s Research Validated by Independent Japanese Study

The Roskamp Institute announced on December 14, 2007 that an independent Tokyo Medical University study validates its ongoing research into the Alzheimer’s Disease drug Nilvadipine which is in testing. The International Journal of Geriatric Psychiatry details the results of study that suggests that Nilvadipine can prevent in people with memory problems the onset of Alzheimer’s. […]

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Roskamp Institute Receives Award of Appreciation

On December 6, 2007 the Economic Development Council (EDC) of the Manatee Chamber of Commerce presented the Roskamp Institute with the 2007 Innovation and Technology Award. The EDC honored the Institute since it has made meaningful contributions to scientific research as it studies neuropsychiatric and neurodegenerative conditions, especially Alzheimer’s Disease. The Roskamp Institute and EDC […]

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Roskamp Institute Studying Potential Usefulness of Beta-amyloid in Treating Alzheimer’s

The Roskamp Institute is currently determining whether beta-amyloid, a protein, is useful in the screening of individuals who are at risk of developing Alzheimer’s Disease and monitoring how current sufferers are responding to treatments. Scientists at the Institute have published their scientific findings that indicate that beta-amyloid could serve as an important biomarker for the […]

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Nilvadipine an anti-hypertensive drug, as a potential treatment for Alzheimer’s disease

    The recent findings showing that certain anti-hypertensive (drugs which lower hypertension) drugs may be helpful in Alzheimer’s disease, is consistent with the work of the Roskamp Institute. The Roskamp Institute has been conducting pioneering research in this area for several years and is currently conducting a clinical trial in Europe to test whether a […]

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Anti-hypertension Drugs and Alzheimers

Alzheimers Disease is afflicting millions world wide and the cost of care runs in several billions. Researchers are working hard to find a cure for Alzheimers Disease. Roskamp Insititute, Sarasota, Florida is currently doing clinical trials with Nilvadipine (an anti-hypertension drug that blocks L-type Calcium Channels) in Ireland. Several research is being also conducted to […]

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The Traumatic Brain Injury Program at the Roskamp Institute

The Traumatic Brain Injury Program at the Roskamp Institute Among the soldiers who survive conflicts in Iraq and Afghanistan, the traumatic brain injuries account for a larger proportion of their casualties than in any other US war in recent history. According to the Joint Theater Trauma Registry, established by the U.S. Army Institute of Surgical […]

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Roskamp Institute Aims to Help Injured Soldiers

Jeremy Willis of the Herald Tribune reports that U.S. Senator Bill Nelson is touring Florida during his congressional August vacation, and Melanie Marquez of the Bradenton Times explains that Nelson learned during his visit to the Roskamp Institute yesterday that it is conducting federally funded research that could help soldiers with traumatic brain injuries. The […]

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Down Syndrome Patient Learning New Skills

St. Louis area Down Syndrome patient Colin Goodwin, 18, spent his summer exploring three different jobs while volunteering at a local fire station, reports the Southwest County Journal. St. Louis Arc’s Neighborhood Experiences program matches people like Goodwin who have cognitive conditions with local businesses and organizations to help them develop job skills and establish […]

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Tracking Wandering Alzheimer’s Sufferers

One of the biggest fears that Alzheimer’s caregivers have are that those to whom they attend to will wander off — potentially finding themselves lost and in danger.  Associated Press medical writer Lauran Neergaard talks about a few options in her article today titled “Helping find lost Alzheimer’s patients.”  She discusses cheap devices that cost […]

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Alzheimer’s Caregiver Training

The Associated Press reports in an article about Alzheimer’s caregiving today that “Offering simple training to people struggling to care for loved ones with Alzheimer’s disease not only eases their burden — it even can keep patients out of nursing homes for an extra 1 1/2 years.” However, many people who care for loved ones […]

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The Roskamp Institute Is Good for Manatee County, Florida

The Bradenton Herald reports that at an economic development panel discussion on Friday sponsored by the Manatee Economic Development Council that, as a panelist, Roskamp Institute director Michael Mullan revealed that his organization brings top researchers to the area.  It also provides skilled, technical jobs, but unfortunately it is hard to find suitable lab technicians […]

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Sarkozy Vows to Defeat Alzheimer’s

The Associated Press reports that French President Nicholas Sarkozy has declared his commitment to curing Alzhemier’s Disease as he visited a retirement home and geriatric hospital wing in Dax, France. Before winning this year’s election, he in May asserted the importance of “doctors with the means to find the solution. The objective must be the […]

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Neuropsychology

Neuropsychology — which examines how human behavior, cognition, and emotion relate to the brain — is one of many fields that the Roskamp Institute uses to address health issues related to memory and Alzeheimer’s. For more information about it, read the journal titled Neuropsychology.

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Sarasota’s Roskamp Institute Announces Participation in Multiple Sclerosis Study

We have just put out a press release announcing the Roskamp Institute’s participation in a multiple sclerosis study. Here’s a quote from Michael Mullan: “We are looking for volunteers to participate in this pharmaceutical sponsored research study to assess the effectiveness and safety of the investigational drug fingolimod, used to treat patients with relapsing-remitting MS,” […]

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Roskamp Institute recruiting for clinical trials

One of the key aspects of our research at the Roskamp Institute is clinical trials.  Without qualified volunteers, our work is impossible. We are currently recruiting volunteers for our clinical trials, which are run by our Scientific Director, Michael Mullan, MBBS, Ph.D.  We are currently recruiting for clinical trials on the following diseases. Alzheimer’s Disease […]

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Roskamp Institute Announces New Class Of Drugs That Can Impact Alzheimer’s Disease

On January 25th, we announceed the discovery of a new class of drugs that lower the production of the main pathological protein that causes Alzheimer’s diseas. Our annoucement got picked up in the press. Following is a roundup of press mentions: Sarasota’s Roskamp Institute Discovers New Class Of Drugs That Can Impact Alzheimer’s Disease Medical […]

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