An exciting research study has concluded at Johns Hopkins University and the results could be great news for the millions of patients who suffer from Alzheimer’s dementia. Epilepsy is a common neurological disorder that affects more than 50 million people in the world. A new drug, antiepileptic levetiracetam, has proved to be successful in reducing […]
Cell stress magnified by chronic disease All of us undergo stress, but those dealing with chronic illnesses such as cancers, diabetes, inflammatory diseases, and neurological degenerative diseases such as Parkinson’s and Alzheimer’s are at an increased level of danger due to a naturally occurring cell stress control mechanism. However, according to a newly released study, […]
From the University of Liverpool and Callaghan Innovation in New Zealand comes a study that local scientists have been developing; a new kind of chemical approach that will harness the natural ability of complex sugars in the treatment Alzheimer’s disease. The team of scientists produced a new library of sugars called heparan sulphates, which […]
Researchers at Lund University in Sweden headed by Professor Singerup Linse and Erik Helistrand have recently identified a molecular mechanism behind the crucial step in Alzheimer’s that leads to the death of brain cells. The neurological disease is associated, as a general statement, with memory loss and changes in personality. The research at Lund […]
A recently completed study at the University of Exeter showed that people with long-lived parents had a twenty-four percent decreased chance of getting cancer. The parameters of ‘long-lived’ defined as mothers who lived past ninety-one years and fathers who lived past eighty-seven years. A side study posted from the National Institute for Health and […]
Within the journal Science, University of Pittsburgh Graduate School of Public Health scientists confirm that a study performed on mouse models of Alzheimer’s disease had significantly improved brain function and memory capabilities after being treated with an anti-cancer drug. The cancer drug, known as bexarotene, has previously been studied and used for the treatment cutaneous […]
At Queen Mary University in London, researchers have conducted the largest study of genetic sequencing of human diseases known to date, identifying the genetic basis of six different diseases: autoimmune thyroid disease, celiac disease, Crohn’s disease, psoriasis, multiple sclerosis, and type 1 diabetes. According to the study, though the exact causes of these diseases […]
A study published in the May 2013 online issue of Neurology follows researchers in Minneapolis who performed a study where 1,102 participants, of an averaged an age of 79, were followed for the span of 3.7 years and tested to see if ever they developed dementia. At the start of the study, 109 of the […]
According to Northwestern Medicine Research, new experimental molecules have great promise in targeting enzymes in the brain that prevent memory loss in Alzheimer’s disease. Developed in D. Martin Watterson’s laboratory, the molecules halted memory loss and were able to fix damaged communication between brain cells in mice. Researchers identified and targeted a key enzyme: a […]
Drs. David Holtzman and Mac Diamond of the Washington University School of Medicine recently published research in Neuron that outlined the process of studying mice for potential tau protein tangle treatment avenues. Tau is a toxic component of Alzheimer’s and other neurodegenerative diseases, due to the protein’s tendency to amass in tangles. The aggregates, called […]
Cedars-Sinai scientists published a study in Journal of Clinical Investigation that suggests ACE inhibitors, in the right context and at the right time, can be a good thing. Many people with high blood pressure take ACE inhibitors, medication meant to widen blood vessels by limiting activity of ACE (angiotensin-converting enzyme), a naturally occurring protein. […]
Researchers at Houston Methodist’s Nantz National Alzheimer Center are studying an investigational drug to slow brain cell deterioration in patients with mild to moderate Alzheimer’s disease. T-817MA focuses on preventing brain cell loss and slowing disease progression, where current treatment options like Donepezil, Rivastigmine, and Memantine only treat the symptoms. The scientists want to know […]
A study conducted recently at the Univeraity of California- San Francisco published online in JAMA Internal Medicine. The research was focused in on finding a close link between diabetes and dementia. According to the journal, diabetic patients with low blood sugar may have an increased risk of developing dementia, and patients with dementia or other […]
Researchers at Sanford-Burnham Medical Research Institute have developed the first experimental drug named NitroMemantine that boosts brain synapses lost to Alzheimer’s disease. The medication combines two FDA-approved drugs to stop destructive cascades within the brain, which destroys the connections between neurons and ultimatly leads to memory loss and a decline in cognition. Dr. Stuart A. […]
Researchers at the Michigan Alzheimer’s Disease Center discovered that flavored ECGC, or epigallocatechi-3-gallate, found in green tea could bind to the toxic protein beta-amyloid and prevent its build-up. When ECGC binds to the protein, it is able to change beta-amyloid’s properties. Dr. Mi Hee Lim, lead researcher of the study, found that ECGC bonded to […]
A recent report from researchers at the Massachusetts General Hospital which identifies a protein that aids the immune system in the removal of A-beta protein from the brain, could lead to new treatments of Alzheimer’s disease. According to cocorresponding author of the report, Dr. Joseph Eli Khoury of the Center for Immunology and Inflammatory Diseases […]
Researchers at Duke University have identified a new type of neuron within the adult brain capable of directing stem cells to make new neurons. The experiments are preliminary, but the hope is that the brain one day could be healing itself from within. Chay Kuo, M.D, Ph.D., an assistant professor of cell biology, neurobiology, and […]
A recent study from University of California, San Francisco scientists found that a chemical in anti-wrinkle cream could effectively prevent the death of nerve cells that had been damaged by mutations which cause an inherited form of Parkinson’s disease. According to the study’s senior scientist, UCSF chemist Kevan Shokat, PhD; the study targeted an enzyme […]
Mayo clinic researchers demonstrated within a mouse model that a synthetic peptide carrier works to deliver brain cancer chemotherapy drugs, as well as neurological medications. Neuroscientist Gobinda Sarkar, Ph.D, of the Mayo Clinic and corresponding author of the study discussed that they were able to transport eight different molecules, and much less disruptively through the […]
According to research by the Washington University School of Medicine, published in Science Translational Medicine, a common antidepressant can reduce the production of brain plaques. Brain plaques correlate closely with memory problems and other cognitive impairments caused by Alzheimer’s disease. Stopping plaque buildup is believed to help halt the mental decline of Alzheimer’s patients. Scientists […]
Amino Acids Improve Sleep in Mice with Traumatic Brain Injury A study by Oregon Health and Science University, published in Science Translational Medicine, discovered a way to fix sleep disturbances in mice suffering from traumatic brain injury. These results are important, because people commonly experience long-term and severe sleep and wakefulness issues after suffering concussions, […]
In a recent study, scientists at the Queensland Brain Institute (QBI) at the University of Queensland and Harvard University have found in their research that the length of the mitochondria may be related to Alzheimer’s treatment. Mitochondria are organelles that metabolize energy for the all the cells. The scientists found in cases where there were […]
A new study recently published in the journal Annals of Neurology discussed the identification of what could be the earliest-known biomarker that is associated with the risk of developing Alzheimer’s disease. Results of the study showed that the biomarker was present within Cerebral Spinal Fluid (CSF) for at least a decade before any signs of […]
Perform a web search on “brain scam” and you will find several articles questioning the veracity of claims made with respect to brain fitness or brain exercise programs. Are these programs a scam? One thing is clear, they appear to be rapidly increasing in popularity – all the way from self help books and DVDs […]
More than 20 years ago, scientists at The Roskamp Institute were among those to first discover the first known genetic cause of Alzheimer’s disease. The discovery had major consequences: The genetic errors were discovered in the amyloid gene. This discovery focused attention on amyloid and it is now recognized as a critical component of all […]
Please visit Mullan Alzheimer website for new information: (http://www.mullanalzheimer.com)
A study entitled “Potent anti-angiogenic motifs within the Alzheimer’s β-amyloid peptide” was published in the January 2008 issue of the journal Amyloid. Building on previous work by Dr. Michael Mullan showing that the Alzheimer’s Aβ peptide is able to prevent blood vessel growth and inhibit tumor growth, Dr. Michael Mullan and other Roskamp Institute scientists […]
Medications that reduce inflammation known as non-steroidal anti-inflammatory drugs (NSAIDS) do not improve thinking abilities in normal seniors. These findings from the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) were published this month in Archives of Neurology. The Roskamp Institute Memory Clinic in Tampa was one of a handful of centers across the United States that […]
Dr. Crawford presented the Roskamp Institute Gulf War Illness research program to the Research Advisory Committee on Gulf War veterans illnesses on June 28-29th at the Veterans Administration in Washington, DC. Her presentation included details of genomic and proteomic analyses of laboratory models of exposure to agents that have been implicated in GWI, which is […]
Laila Abdullah will be presenting the paper on Friday (7/2/2010) at Roskamp Institute. Title:Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1–neuregulin cascade Journal: PNAS 5622–5627 | March 23, 2010 | vol. 107 | no. 12 Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter […]
Nowell (Jim) Ganey will be presenting the paper on Friday (6/25/2010) at Roskamp Institute. Title:The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease. Journal : Biomaterials. 2010 Jul;31(21):5608-18. Epub 2010 Apr 28. Journal Club is held every Friday between 4 Pm-5pm. For change in […]
The Roskamp Institute has been nominated for a Business/Education Partnership Award through the School District of Manatee County‘s ePIE program. Since 1990, this awards program recognizes businesses, organizations, and individuals who have made the commitment to work together to enhance education in the School District of Manatee County. The awards ceremony will be held in August. […]
On Tuesday June 15th the Roskamp Institute was recognized by the South East High School Technical Student association for partnering will the in a diabetes project. At the Victory celebration banquet held at South East High following the TSA teams success in the State TSA finals. The Diabetes project was awarded second place in the […]
The Roskamp Institute continues to actively recruit clinical research participants for the treatment of both Alzheimer’s disease and Multiple sclerosis. We are proud to share the following press announcement regarding a clinical trial/potential treatment that Roskamp Institute has been involved in since 2006: “FDA advisory committee unanimously recommends approval of Novartis investigational treatment FTY720 to […]
Scott Ferguson will be presenting the paper on Friday (6/18/2010) at Roskamp Institute. Title:NF-κB activity affects learning in aversive tasks: Possible actions via modulation of the stress axis Journal: Brain, Behavior, and Immunity doi:10.1016/j.bbi.2010.04.005 Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter account or facebook page. […]
Bradenton Herald Business section published an article about on going collaboration between Roskamp Institute and Southeast High school students. You can reach it via this link.
By S. FERGUSON,a* B. MOUZON,a G. KAYIHAN, a M. WOOD, a F. POON, a S. DOORE, a V. MATHURA, a J. HUMPHREY, a B. O’STEEN, b R. HAYES, c A. ROSES, d M. MULLANa AND F. CRAWFORDa aThe Roskamp Institute, 2040 Whitfield Avenue, 34243, Sarasota, FL, USA bCenter for Traumatic Brain Injury Studies, McKnight Brain […]
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice by Rhein et al. Alex Bishop will be presenting the paper on Friday (6/11/2010) at Roskamp Institute. Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter account or facebook page. The Roskamp […]
Benoit Mouzon will be presenting “Blood-brain barrier breakdown and repair by Src after thrombin-induced injury” by Liu et al. The journal club will start at 4:00pm on Friday (may 28th 2010) in the auditorium at Roskamp Institute. The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. […]
The Roskamp Institute Memory Center and Clinical Trials Division is pleased to announce the addition of Ms. Yahdinah Alvarez to the clinical team. Ms. Alvarez is an experienced clinical trial coordinator with expertise in Alzheimer’s and Parkinson’s disease studies. If you or your loved one is suffering with Alzheimer’s disease or Parkinson’s disease, please contact […]
2nd Annual Science, Technology, Engineering & Math (S.T.E.M.) Summit at USF Sarasota-Manatee on Saturday, will start at 9 AM in May 22nd. Dr Crawford will give a speech about women in science. For more information visit S.T.E.M. website. The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and […]
By Patel NS, Mathura VS, Bachmeier C, Beaulieu-Abdelahad D, Laporte V, Weeks O, Mullan M, Paris D. Published in J Neurochem. 2010 Jan;112(1):66-76. Roskamp Institute, Sarasota, Florida, USA. email@example.com Abstract Beta-amyloid peptides (Abeta) are the major constituents of senile plaques and cerebrovascular deposits in the brains of Alzheimer’s disease patients. We have shown previously that […]
By our own MS guru Jon Reed A Thermo Engineer once told me that “Nano-LC is not for the faint-of-heart.” A 0.5µl bubble in a 10-port valve can make a mess of an experiment. Incomplete proteolytic digestions can clog up your brand new $600 column and render it useless. A few centimeters of post-column dead […]
ALZHEIMER’S DISEASE A research study is being conducted in our area to evaluate an investigational medication for Alzheimer’s disease. Qualified participants may receive: – Study related medical care – Study medication – Compensation for time and travel Please call now for more info: Dr. Andrew Keegan 941-256-8018 ext. 353 The Roskamp Institute Memory Clinic and […]
By Daniel Paris*, Nowell J Ganey, Vincent Laporte, Nikunj S Patel, David Beaulieu-Abdelahad, Corbin Bachmeier, Amelia March, Ghania Ait-Ghezala, Michael J Mullan published in Journal of Neuroinflammation 2010, 7:17 Abstract Background: Ab deposits represent a neuropathological hallmark of Alzheimer’s disease (AD). Both soluble and insoluble Ab species are considered to be responsible for initiating the […]
Media Contact: Cheryl Rindfleisch, Roskamp Institute 941-256-8018 x356 firstname.lastname@example.org or Jeffree Itrich 858-622-5827 email@example.com May 10, 2010 Investigational Immune Intervention Slows Brain Atrophy in Alzheimer’s Patients 18-Month Phase 2 Study is First to Show Combined Benefits of IGIV on Clinical Outcomes and Brain-Imaging Measures Phase 3 Study Now Enrolling Participants at the Roskamp Institute in […]
Jeremy Frieling is presenting “Days-to-criterion as an indicator of toxicity associated with human Alzheimer amyloid- oligomers” by Gandy et al. Location: Roskamp Institute Date: May 14th 2010 Time: 4:00PM The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific […]
Are you or someone you know suffering from memory loss or forgetfulness? Roskamp Institute is offering FREE MEMORY SCREENING for adults age 60 or older. For an appointment call: Roskamp Institute 941-256-8018 ext. 349 The Roskamp Institute Memory Clinic and Clinical Trials Division provide a full range of services for individuals with Alzheimer’s disease […]
By Daniel Paris • Nikunj Patel • Nowell J. Ganey • Vincent Laporte • Amita Quadros • Michael J. Mullan Int J Pept Res Ther (2010) 16:23–3. DOI 10.1007/s10989-010-9198-8 Abstract: The inhibition of angiogenesis is regarded as a promising avenue for cancer treatment. Although some antiangiogenic compounds are in the process of development and testing, […]
By Ait-ghezala G, Abdullah L, Volmar CH, Paris D, Luis CA, Quadros A, Mouzon B, Mullan MA, Keegan AP, Parrish J, Crawford FC, Mathura VS, Mullan MJ. Cytokine. 2008 Nov;44(2):283-7. A continuous inflammatory state is associated with Alzheimer’s disease (AD) evidenced by an increase in proinflammatory cytokines around beta-amyloid (Abeta) deposits. In addition, functional loss […]
By Volmar CH, Ait-Ghezala G, Frieling J, Weeks OI, Mullan MJ. Exp Cell Res. 2009 Aug 1;315(13):2265-74. CD40, a member of tumor necrosis factor receptor superfamily, and its cognate ligand CD40L are both elevated in the brain of Alzheimer’s disease (AD) patients compared to controls. We have shown that pharmacological or genetic interruption of CD40/CD40L […]
As I mentioned before, most of the PhD students and research assistants from our Institute participated in poster session that was organized as a part of VA Research Week event series. Here you will find the abstract of our posters, enjoy 🙂 Development of the Barnes Maze as an Alternative to the Morris Water Maze […]
Venkatarajan S. Mathura Complex information that are available in a crude format make computational modeling and processing a difficult objective in Biological and Health care research. Protocol revisions, process flexibility, user adoptability should be considered in mind to develop an user friendly information management solution. There is a great need to integrate data from several […]
By Our Mass Spectrometry Guru Jon Reed This will be the first in an ongoing series of technical tips for those interested in biochemistry and mass spectrometry. Anyone involved with these fields knows there can be considerable headache and heartache that goes hand-in-hand with even the simplest of experiments. Along the way, I’ve picked up […]
Veterans Affairs is celebrating 85th year in research this week (April 26-30, 2010). One of the events is a poster session where scientists will be presenting their most recent work. We are proud to say that most of our PhD students and research assistants will be in the auditorium of the James A Haley VA […]
Dr. Corbin Bachmeier of the Roskamp Institute is currently investigating the drug efflux transport interactions of various antidepressants in collaboration with Dr. Gary Levin of the Lake Erie College of Osteopathic Medicine (LECOM) in Bradenton, FL. Dr. Bachmeier and Dr. Levin are co-investigators of a grant, provided by Wyeth Pharmaceuticals, which examines the interactions of […]
Alzheimer’s disease is clinically characterized by progressive cognitive decline accompanied by the presence of amyloid plaques and neurofibrillary tangles in the brain of Alzheimer’s patients. A small protein fragment beta-amyloid (Abeta) with 42 amino acids is shown to deposit earlier in the disease process than the slightly shorter form (40 amino acid fragment). Both species […]
JC Nowell Ganey will present “The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia” on Thursday (29th April 2010) at 4:00pm in Roskamp Institute. You can find the article in the following link. The Roskamp Institute provides a full range of services for individuals with Alzheimer’s disease including diagnostic work-up […]
The Roskamp Institute Memory Center is actively following a large number of subjects who participated in the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT). Although earlier detection and the development of disease modifying treatment continues to be a primary focus of research and several potential compounds are under clinical trial, more prevention studies are needed. The […]
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A methodology is described for use of a 16-hole circular platform task to test spatial memory in mice. Both bright light and a fan were used to motivate mice to escape the platform surface through a single hole containing an attached escape box. For each daily trial, three correlated measures (escape latency, number of errors, […]
Fiona Crawford1, Zhiming Suo, Chunhong Fang and Mike Mullan Roskamp Laboratories, Department of Psychiatry, 3515 East Fletcher Avenue, University of South Florida, Tampa, Florida, 33613 Abstract The β-amyloid (Aβ1–40) peptide has previously been shown to enhance phenylephrine contraction of aortic ringsin vitro.We have employed a novel observation, that Aβ peptides enhance endothelin-1 (ET-1) contraction, to […]
Daniel Paris email, Nowell J Ganey email, Vincent Laporte email, Nikunj S Patel email, David Beaulieu-Abdelahad email, Corbin Bachmeier email, Amelia March email, Ghania Ait-Ghezala email and Michael J Mullan email The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA author email corresponding author email Journal of Neuroinflammation 2010, 7:17doi:10.1186/1742-2094-7-17 Published: 8 March 2010 […]
By Cheryl A. Luis, Andrew Keegan, and Michael Mullan Int J Geriatr Psychiatry. 2009 Feb;24(2):197-201. Suitable methods of earlier detection of memory changes, before the full onset of a dementia are needed. Methods such as imaging for abnormal protein accumulation in the brain and lumbar puncture to measure abnormal proteins in cerebral spinal fluid are […]
Dr. Cheryl Luis of the Roskamp Institute was awarded a New Investigator Research Grant from the Alzheimer’s Association in 2009. She is studying the potential usefulness of a blood test in combination with a paper and pencil memory test for early detection of cognitive decline in older adults. Additional research volunteers are needed. If you […]
Sarasota, FL The Roskamp Institute hosted a town hall meeting for the Alzheimer’s Association. Presented was “A Reason to Hope”, an Alzheimer’s Services and Treatment Update. The meeting was well attended by caregivers and local community leaders. Dr. Cheryl Luis, Associate Clinical Director of the Roskamp Institute Memory Center, presented some of her current research […]
Sarasota, Fla. Dr. Daniel Paris, a senior scientist of the Roskamp Institute, was awarded an Investigator Initiated Research Grant Award from the Alzheimer’s Association to investigate the preclinical efficacy of a natural compound (celastrol) in a genetically engineered mouse model of Alzheimer’s disease. The brain of Alzheimer’s disease patients is characterized by the accumulation of […]
Sarasota, FL The Roskamp Institute today announced that its researchers have uncovered a new link between inflammation and Alzheimer’s disease and have identified a potential target for developing novel therapeutics for intervention in this disease. The study, led by Roskamp Institute’s Pancham Bakshi, Ph.D., is detailed in the American Chemical Society’s Chemical Biology Journal, a […]
Sarasota, FL Sarasota’s Roskamp Institute (Roskamp) today announced the first enrollment of students in its pioneering three-year Ph.D. program through which students will conduct full-time laboratory research with direct mentoring from internationally-recognized scientists. Roskamp is an Affiliated Research Centre (ARC) of the United Kingdom’s Open University (OU) and was recently granted a license from the […]
Sarasota, FL Roskamp Institute was the focus of Southeast High Technology Student Association (TSA) team project in the Medical Technology category which was awarded fifth place in the Nation at the 31ST Annual TSA National Conference in Denver, Colorado June 28 – July 2 after wining first place in the State of Florida competition held […]
This summer, researchers from Roskamp Institute in Sarasota, FL, will begin testing an investigational approach to slowing down the progression of Alzheimer’s disease (AD) using Intravenous Immune Globulin (IGIV), also known as gammaglobulin. IGIV is currently used to treat primary immunodeficiency disorders but is not currently approved for treating AD, which is one of the […]
Alzheimer’s disease carries an annual price tag of $148 billion dollars, not to mention the personal toll that it takes on the over 5.3 million patients and their families. More than 5.3 million Americans are living with Alzheimer’s, and every 72 seconds someone in America develops the disease. According to the Alzheimer’s Association, by mid-century […]
A recent paper published in the Journal Neurology, which analyzed over 900 people, suggests that almost half of all women in their nineties are suffering from dementia. The study carried out in California is one of a few looking specifically at the rates of dementia in the very old. However, given our increased life expectancies, […]
The relationship between blood pressure and Alzheimer’s disease is complex. However, we do know that blood pressure raised in mid-life (hypertension) is a risk for the development of Alzheimer’s disease later on. Uncontrolled hypertension is a risk for dementia in general. In fact, stroke related dementias are primarily caused by either clotting or small bleeds […]
Alzheimer’s disease is a neurodegenerative disorder (i.e., one which attacks neurons in the brain) which robs us of our memories, language, reasoning and thought. However, the clinical picture of Alzheimer’s has a very distinctive pattern which distinguishes it from other forms of dementia (dementia is a general term which simply means the loss of memory, […]
A recent paper (June 22nd from scientists from Harvard University and Trinity College, Dublin) has shown that the amyloid protein is most toxic to memory when it appears in a double form. The researchers extracted the amyloid protein (the small protein that has long thought to be the cause of Alzheimer’s) from the brains of […]
In 1991, researchers currently at the Roskamp Institute published a paper in the highly prestigious Nature journal entitled “Early Onset Alzheimer’s Disease Caused by Mutations of the Amyloid Gene”. This and related findings were historic milestones in the understanding of the causes of Alzheimer’s disease. Today, seventeen years later, Roskamp Institute researchers are delighted to […]
The Roskamp Institute has a commitment to bring state-of-the-art new therapies to our patients at both the Sarasota and Tampa sites. For Alzheimer’s disease, for instance, the Institute is taking part in the Elan Wyeth clinical trials of a vaccine for Alzheimer’s disease. Important results for the Elan Wyeth vaccine were released on June 17, […]
An article in the Wall Street Journal on the 18th of June 2008, encapsulates the current expectation, hope and knowledge in the field of Alzheimer’s disease research. Researchers at the Roskamp Institute (Institute) have been part of the history of the discovery of new possibilities for stopping this devastating disease. The article importantly discusses the […]
Clinicians at the Roskamp Institute are conducting a clinical trial for Elan Pharmaceuticals, Inc. of San Francisco and Transition Therapeutics, Inc. of Toronto, Canada. The drug is designated ELND005 and the study is a phase two study in mild to moderate Alzheimer’s disease. ELND005 is an orally available drug that is designed to prevent the […]
The Roskamp Institute (Institute) is engaged in the study of drug addiction from a genomic and proteomic perspective. The genomic analysis, which covers the examination of all the genes in the human genetic make-up allows research at the Institute to determine which genes respond in relation to exposure to certain drugs of addiction. The proteomic […]
An article in the New England Journal of Medicine entitled “Traumatic Brain Injury in the War Zone” details the experiences of a supply officer with a US Army Stryker Brigade after suffering a head injury in Northern Iraq in a convoy transporting Iraqi volunteers to Mosul for military training. The officer reported remembering that the […]
A recent article in the New England Journal of Medicine emphasizes the important medical consequences of Traumatic Brain Injury (TBI) in US soldiers returning from Iraq. Although the exact number of combat related TBIs is not known, in a survey of over 2500 soldiers returning from Iraq, almost five percent reported injuries with loss of […]
Roskamp Institute has previously worked extensively on the ability of amyloid (the main protein that causes Alzheimer’s disease) to stop the growth of blood vessels. Although this is bad news in Alzheimer’s and probably contributes to the decline in cognitive function the effect has been turned to good use in other areas. The Roskamp Institute […]
In September of 2004, the research advisory committee on Gulf War veteran’s illnesses produced a report and recommendation on the scientific progress and understanding the complex condition known as Gulf War Syndrome. This report suggested that important contributors to Gulf War Syndrome included the nerve agent prophylaxis pill, pyridostigmine bromide, pesticide exposure and potentially anthrax […]
The Roskamp Institute is one of many sites nationally that has been chosen to conduct a clinical trial in Alzheimer’s disease using a vaccine approach. Although the mechanism of action of vaccine is unknown, the original idea was that antibodies would circulate in the body and find the amyloid protein in the brain. There are […]
The Roskamp Institute has received an award from the James & Esther King Biomedical Research Program grant for your project titled “Treatment of Lung Adenocarcinoma and Metastasis by Anti-angiogenic Fragments of Abeta.” The award was based on the scientific merit assigned to the proposal by qualified peer reviewers and other factors considered by the Biomedical […]
Mainly two cerebral lesions characterized Alzheimer’s disease (AD): an extracellular deposition of the beta-amyloid peptide (Abeta) in senile plaques and an intracellular accumulation of neurofibrillary tangles (principally composed of protein tau). Besides these lesions, a continuous inflammatory state exists in the brain of AD patients. In AD brains, the tau protein becomes hyper-phosphorylated and acquires […]
Alzheimer disease is the most common cause of dementia, afflicting 24 million people worldwide. Over time, Alzheimer’s disease gradually destroys a person’s memory and ability to learn and carry out daily activities. In addition; individuals may also experience changes in personality and behavior. Alzheimer disease is accompanied by the presence of amyloid plaques and neurofibrillary […]
Roskamp Institute study entitled “Potent anti-angiogenic motifs within the Alzheimer’s β-amyloid peptide” was published in the January 2008 issue of the scientific journal Amyloid. Work by Dr. Michael Mullan and Dr. Daniel Paris showed that a protein central to Alzheimer’s disease pathology is also able to prevent blood vessel growth and stop tumors. In our […]
Alzheimer’s disease (AD) is the most common type of dementia in the elderly. AD is mainly characterized by the accumulation of a small molecule (known as amyloid beta (Abeta)) in the brain. Many researchers have shown that the molecule CD40L is elevated in AD patients. Roskamp Institute research group headed by Dr. Michael Mullan also […]
A study entitled “Potent anti-angiogenic motifs within the Alzheimer’s β-amyloid peptide” was published in the January 2008 issue of the journal Amyloid. Building on previous work showing that the Alzheimer’s Aβ peptide is able to prevent blood vessel growth and inhibit tumor growth, Roskamp Institute scientists investigated particular sequences within the Alzheimer’s Aβ peptide in […]
Medications that reduce inflammation known as non-steroidal anti-inflammatory drugs (NSAIDS) do not improve thinking abilities in normal seniors. These findings from the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) were published this month in Archives of Neurology. The Roskamp Institute Memory Clinic in Tampa was one of a handful of centers across the United States that […]
Non-steroidal anti-inflammatory (NSAIDS) drugs such as Naproxen and Celecoxib do not improve cognition in at-risk older adults. These findings from the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) were published this month in Archives of Neurology. The Roskamp Institute Memory Clinic in Tampa was one of a handful of centers across the United States that took […]
Florida Trend has recently published a lengthy article on the growing technology cluster in the Tampa Bay region in its September 24th article “Tampa Bay: Research Reigns.” The Roskamp Institute adds to the area’s biotech sector as it researches cures for neuropsychiatric and neurodegenerative disorders and has a new neuroscience doctoral research program. Visit the […]
The James & Esther King Biomedical Research Program has awarded Dr. Daniel Paris of The Roskamp Institute the Small Business Technology Transfer Grant for $100,000 to conduct a research project titled: “Treatment of Lung Adenocarcinoma and Metastasis by Anti-angiogenic Fragments of Abeta.” The Institute has previously shown that the Abeta peptite can help inhibit the […]
The Sarasota Herald Tribune reported yesterday that the Roskamp Institute was nominated for an Image Manatee Beautification Award. The Manatee Chamber of Commerce recognizes local businesses and organizations each quarter that contribute to the natural beauty of the area through their building design, use of drought-resistant landscaping, and other factors. Visit the Roskamp Institute website […]
FloridaTrend.com, a site covering business issues, explained in its article “SOUTHWEST: Eye Opener” on April 1st that the Roskamp Institute’s new neuroscience doctorate program is attracting researchers to Manatee County, which is suffering from layoffs in the home construction sector. These researchers and the facility’s work help bring more money to the county’s economy. Learn […]
Roskamp Institute Director Dr. Michael Mullan was one of many who represented the biotech industry at the Biotechnology Legislative Caucus yesterday to request more state funding in helping the industry thrive in the state. This is important to Florida this would help the state diversify its economy more, and many organizations within the state have […]
As reported in today’s Bradenton Herald, the Roskamp Institute is searching for clinical trial participants for two potential Alzheimer’s disease treatments. Bapineuzumab and ELND005 are being tested; both hope to successfully remove plaque from the brain which helps cause the condition. For more information please visit the Roskamp Institute Clinical Trial Division web page.
The Sarasota Herald-Tribune reports today in an article titled “In quest to unravel Alzheimer’s, drug may soon be tested locally” that The Roskamp Institute is planning to conduct a clinical trial of a potential Alzheimer’s disease treatment this summer. It will occur in the Sarasota, Florida area, where the Institute is located.
The Roskamp Institute’s associate director Fiona Crawford will be one of three panelists during the New College Foundation’s discussion “The Power of Women in Education” that takes place Tuesday, February 12 at the Senior Pavilion. To learn more call 487-4800 or e-mail PoWfirstname.lastname@example.org.
The Roskamp Institute announced today that it will host a neuroscience doctorate research program as part of The Open University’s — of Milton Keynes, England — Affiliated Research Centre. This is the first program of this kind in Florida and will help students prepare better for researching Alzheimer’s disease and related disorders as they work […]
The Roskamp Institute announced on December 14, 2007 that an independent Tokyo Medical University study validates its ongoing research into the Alzheimer’s Disease drug Nilvadipine which is in testing. The International Journal of Geriatric Psychiatry details the results of study that suggests that Nilvadipine can prevent in people with memory problems the onset of Alzheimer’s. […]
On December 6, 2007 the Economic Development Council (EDC) of the Manatee Chamber of Commerce presented the Roskamp Institute with the 2007 Innovation and Technology Award. The EDC honored the Institute since it has made meaningful contributions to scientific research as it studies neuropsychiatric and neurodegenerative conditions, especially Alzheimer’s Disease. The Roskamp Institute and EDC […]
The Roskamp Institute is currently determining whether beta-amyloid, a protein, is useful in the screening of individuals who are at risk of developing Alzheimer’s Disease and monitoring how current sufferers are responding to treatments. Scientists at the Institute have published their scientific findings that indicate that beta-amyloid could serve as an important biomarker for the […]
The recent findings showing that certain anti-hypertensive (drugs which lower hypertension) drugs may be helpful in Alzheimer’s disease, is consistent with the work of the Roskamp Institute. The Roskamp Institute has been conducting pioneering research in this area for several years and is currently conducting a clinical trial in Europe to test whether a […]
Alzheimers Disease is afflicting millions world wide and the cost of care runs in several billions. Researchers are working hard to find a cure for Alzheimers Disease. Roskamp Insititute, Sarasota, Florida is currently doing clinical trials with Nilvadipine (an anti-hypertension drug that blocks L-type Calcium Channels) in Ireland. Several research is being also conducted to […]
The Bradenton Herald reports that Dr. Fiona Crawford, Roskamp Institute’s associate director, will moderate the “The Power of Women in Medicine and Science” of the Power of Women forum series at Sainer Pavilion of the Caples Fine Arts Complex on Bay Shore Road in Sarasota. The panelists include: Sarasota Memorial Hospital president and CEO Gwen […]
Read this article: http://news.yahoo.com/s/nm/20071001/hl_nm/alzheimers_conscientious_dc
The Traumatic Brain Injury Program at the Roskamp Institute Among the soldiers who survive conflicts in Iraq and Afghanistan, the traumatic brain injuries account for a larger proportion of their casualties than in any other US war in recent history. According to the Joint Theater Trauma Registry, established by the U.S. Army Institute of Surgical […]
U.S. Senator Bill Nelson toured the laboratories and discussed the various types of research currently being conducted at the Roskamp Institute. read more | digg story
Melanie Marquez, a reporter at the Bradenton Herald, reports that Senator Bill Nelson of Florida visited Roskamp Institute yesterday. The institute was recently funded $1.5 million by the US Department of Defense to conduct research in Traumatic Brain Injury (TBI). Roskamp Institute research work may help soldiers like those in Iraq who suffer injury due […]
Jeremy Willis of the Herald Tribune reports that U.S. Senator Bill Nelson is touring Florida during his congressional August vacation, and Melanie Marquez of the Bradenton Times explains that Nelson learned during his visit to the Roskamp Institute yesterday that it is conducting federally funded research that could help soldiers with traumatic brain injuries. The […]
Clare Murphy, BBC health reporter, explains that the procedure to see if a fetus has Down Syndrome is being questioned by British experts since the test can cause a miscarriage of normal babies.
A recent study conducted by scientists in the United States and Portugal have found that BubR1, which affects cell division, apparently plays a role when sperm and egg chromosomes split and form. Apparently, BubR1 causes the chromosomes to mutate and, thus, help led to a person suffering from Down Syndrome.
St. Louis area Down Syndrome patient Colin Goodwin, 18, spent his summer exploring three different jobs while volunteering at a local fire station, reports the Southwest County Journal. St. Louis Arc’s Neighborhood Experiences program matches people like Goodwin who have cognitive conditions with local businesses and organizations to help them develop job skills and establish […]
Reuters reports that US health officials have required Novartis AG to correct misleading information in its advertising and marketing campaign for its Alzheimer’s drug Exelon. The questioned information was printed on file cards distributed to health care professionals.
One of the biggest fears that Alzheimer’s caregivers have are that those to whom they attend to will wander off — potentially finding themselves lost and in danger. Associated Press medical writer Lauran Neergaard talks about a few options in her article today titled “Helping find lost Alzheimer’s patients.” She discusses cheap devices that cost […]
The Associated Press reports in an article about Alzheimer’s caregiving today that “Offering simple training to people struggling to care for loved ones with Alzheimer’s disease not only eases their burden — it even can keep patients out of nursing homes for an extra 1 1/2 years.” However, many people who care for loved ones […]
While the Roskamp Institute tries to cure intellectual disabilities like Down Syndrome, ThinkCollege.net encourages and helps those with such challenges to still pursue post secondary education — including college. This is a great resource for those who have family members and friends who are bright but yet impaired.
For those who have loved ones who have Down Syndrome, here’s an organization that can help you deal with it.
BBC News reports Barbara Pointon, who was the subject of a British TV documentary since he lost her husband to Alzheimer’s Disease, is going to serve as a dementia adviser to the British government. The last 11 years of her husband’s life were documented as he suffered from the condition. She’ll likely serve as a […]
The news aggregating site Topix has an Alzheimer’s Disease discussion forum in which people discuss various news item related to the condition. Check it out.
The Bradenton Herald reports that at an economic development panel discussion on Friday sponsored by the Manatee Economic Development Council that, as a panelist, Roskamp Institute director Michael Mullan revealed that his organization brings top researchers to the area. It also provides skilled, technical jobs, but unfortunately it is hard to find suitable lab technicians […]
Yesterday, the Roskamp Institute released the results of study about obesity and Type 2 Diabetes. Here’s a link to the official press release.
Today the Roskamp Institute announced that one of its studies, led by Dr. Robert Farese, identifies a mechanism behind obesity and Type 2 Diabetes. Although the research center typically focuses on cognitive conditions like Down Syndrome, it is believed that diabetics are more likely to suffer from Alzheimer’s Disease.
The US Federal Government’s site ClinicalTrials.gov is an excellent source of information about various medical tests.
The Associated Press reports that French President Nicholas Sarkozy has declared his commitment to curing Alzhemier’s Disease as he visited a retirement home and geriatric hospital wing in Dax, France. Before winning this year’s election, he in May asserted the importance of “doctors with the means to find the solution. The objective must be the […]
According to Reuters, Dr. Milan Fiala of the Greater Los Angeles Veteran’s Affairs Medical Center found in a laboratory study that a chemical found in the common curry spice turmeric can help boost the immune system of Alzheimer’s Disease patients. Hopefully, these findings are accurate since tumeric is a cheap, readily available substance.
If you’re looking for a science research job, check out the Roskamp Institute careers page.
In an upbeat article from February about the prospects of those who suffer from Down Syndrome and Alzheimer’s Disease, Stephanie Hayes of The St. Petersburg Times explains how the Roskamp Institute‘s trial of a new treatment for Alzheimer’s could further improve the life of those who have the disease.
Neuropsychology — which examines how human behavior, cognition, and emotion relate to the brain — is one of many fields that the Roskamp Institute uses to address health issues related to memory and Alzeheimer’s. For more information about it, read the journal titled Neuropsychology.
John Hopkins University found that Alzheimer’s cases may quadruple by 2050 in a study funded by Elan Pharmaceuticals and Wyeth Pharmaceuticals.
Alzheimer’s is a tough disease to endure or see a love one endure. Find support in the many Alzheimer’s support groups hosted on Yahoo!.
Last year on World Alzheimer’s Day — September 21, 2006 — the Roskamp Institute helped celebrate a day by starting a clinical trial, and for the first time the trial is on a product of Roskamp’s own work. Hopefully, this study will yield positive results for Alzheimer’s research.
The Roskamp Institute is helping with trials for the Alzheimer’s drug Nilvadipine to get it approved for use in the United States, and the Herald Tribune in Florida reports that the human trials are going well. If all goes well with Nilvadipine, we’re one step closer to making life much better for those who suffer […]
Following is a video of a local television show on the Roskamp Institute’s new alzheimer’s treatment. roskamp roskamp institute alzheimers michael mullan
Following is a breakdown of some additional media coverage about the Roskamp Institute’s recent announcement of a new Phase III MS Study to Evaluate the Efficacy and Safety of FTY720. Following is some of the pickups. The Roskamp Institute is Participating in a New Phase III MS Study to Evaluate the Efficacy and Safety of […]
Genetic Engineering and Biotechnology News has the scoop on a new study the Roskamp Institute is conducting. Here are the details: SARASOTA, Fla., April 30 /PRNewswire/ — The Roskamp Institute announced today that it is now screening patients for enrollment in a new Phase III study to evaluate the efficacy and safety of FTY720 (fingolimod), […]
The story we featured a few weeks ago has been picked up by the Orlando Sentinel. You can read the story here. roskamp roskamp institute alzheimers michael mullan
There was a good story a few week’s back that features our Executive Director, Michael Mullan. Here are the key quotes: Because people with Down’s syndrome have an extra copy of that chromosome, they produce more of the protein. A part of that protein, beta-amyloid, builds up as plaque on the brain. “We may still […]
We have just put out a press release announcing the Roskamp Institute’s participation in a multiple sclerosis study. Here’s a quote from Michael Mullan: “We are looking for volunteers to participate in this pharmaceutical sponsored research study to assess the effectiveness and safety of the investigational drug fingolimod, used to treat patients with relapsing-remitting MS,” […]
One of the key aspects of our research at the Roskamp Institute is clinical trials. Without qualified volunteers, our work is impossible. We are currently recruiting volunteers for our clinical trials, which are run by our Scientific Director, Michael Mullan, MBBS, Ph.D. We are currently recruiting for clinical trials on the following diseases. Alzheimer’s Disease […]
On January 25th, we announceed the discovery of a new class of drugs that lower the production of the main pathological protein that causes Alzheimer’s diseas. Our annoucement got picked up in the press. Following is a roundup of press mentions: Sarasota’s Roskamp Institute Discovers New Class Of Drugs That Can Impact Alzheimer’s Disease Medical […]