Publications

Phospholipid profiling of plasma from GW veterans and rodent models to identify potential biomarkers of Gulf War Illness.

Emmerich T, Zakirova Z, Klimas N, Sullivan K, Shetty AK, Evans JE, Ait-Ghezala G, Laco GS, Hattiangady B, Shetty GA, Mullan M, Crynen G, Abdullah L, Crawford F.

PLoS One. 2017 Apr 28;12(4):e0176634. doi: 10.1371/journal.pone.0176634. eCollection 2017.

PMID: 28453542

 

Complementary proteomic approaches reveal mitochondrial dysfunction, immune and inflammatory dysregulation in a mouse model of Gulf War Illness.

Zakirova Z, Reed J, Crynen G, Horne L, Hassan S, Mathura V, Mullan M, Crawford F, Ait-Ghezala G.

Proteomics Clin Appl. 2017 Mar 28. doi: 10.1002/prca.201600190. [Epub ahead of print]

PMID: 28371386

 

Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment.

Shen Y, Wang H, Sun Q, Yao H, Keegan AP, Mullan M, Wilson J, Lista S, Leyhe T, Laske C, Rujescu D, Levey A, Wallin A, Blennow K, Li R, Hampel H.

Biol Psychiatry. 2017 Mar 27. pii: S0006-3223(17)30098-7. doi: 10.1016/j.biopsych.2017.02.007. [Epub ahead of print]

PMID: 28359566

 

APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer’s Disease.

Abdullah L, Evans JE, Emmerich T, Crynen G, Shackleton B, Keegan AP, Luis C, Tai L, LaDu MJ, Mullan M, Crawford F, Bachmeier C.

Aging (Albany NY). 2017 Mar 23;9(3):964-985. doi: 10.18632/aging.101203.

PMID: 28333036

 

Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness.

Abdullah L, Evans JE, Joshi U, Crynen G, Reed J, Mouzon B, Baumann S, Montague H, Zakirova Z, Emmerich T, Bachmeier C, Klimas N, Sullivan K, Mullan M, Ait-Ghezala G, Crawford F.

Toxicology. 2016 Nov 30;372:22-33. doi: 10.1016/j.tox.2016.10.012. Epub 2016 Oct 29.

PMID: 27931520

 

Acute or Delayed Treatment with Anatabine Improves Spatial Memory and Reduces Pathological Sequelae at Late Time-Points after Repetitive Mild Traumatic Brain Injury.

Ferguson S, Mouzon B, Paris D, Aponte D, Abdullah L, Stewart W, Mullan M, Crawford F.

J Neurotrauma. 2017 Apr 15;34(8):1676-1691. doi: 10.1089/neu.2016.4636. Epub 2017 Jan 20.

PMID: 27889957

 

Mild TBI Results in a Long-Term Decrease in Circulating Phospholipids in a Mouse Model of Injury.

Emmerich T, Abdullah L, Ojo J, Mouzon B, Nguyen T, Laco GS, Crynen G, Evans JE, Reed J, Mullan M, Crawford F.

Neuromolecular Med. 2017 Mar;19(1):122-135. doi: 10.1007/s12017-016-8436-4. Epub 2016 Aug 19.

PMID: 27540748

 

European multicentre double-blind placebo-controlled trial of Nilvadipine in mild-to-moderate Alzheimer’s disease-the substudy protocols: NILVAD frailty; NILVAD blood and genetic biomarkers; NILVAD cerebrospinal fluid biomarkers; NILVAD cerebral blood flow.

Meulenbroek O, O’Dwyer S, de Jong D, van Spijker G, Kennelly S, Cregg F, Olde Rikkert M, Abdullah L, Wallin A, Walsh C, Coen R, Kenny RA, Daly L, Segurado R, Borjesson-Hanson A, Crawford F, Mullan M, Lucca U, Banzi R, Pasquier F, Breuilh L, Riepe M, Kalman J, Molloy W, Tsolaki M, Howard R, Adams J, Gaynor S, Lawlor B.

BMJ Open. 2016 Jul 19;6(7):e011584. doi: 10.1136/bmjopen-2016-011584.

PMID: 27436668

 

Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers.

Ojo JO, Mouzon B, Algamal M, Leary P, Lynch C, Abdullah L, Evans J, Mullan M, Bachmeier C, Stewart W, Crawford F.

J Neuropathol Exp Neurol. 2016 Jul;75(7):636-55. doi: 10.1093/jnen/nlw035. Epub 2016 May 31.

PMID: 27251042

 

Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury.

Tzekov R, Dawson C, Orlando M, Mouzon B, Reed J, Evans J, Crynen G, Mullan M, Crawford F.

PLoS One. 2016 Apr 18;11(4):e0153608. doi: 10.1371/journal.pone.0153608. eCollection 2016.

PMID: 27088355

Plasma Lipidomic Profiling in a Military Population of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder with Apolipoprotein E ɛ4-Dependent Effect.

Emmerich T, Abdullah L, Crynen G, Dretsch M, Evans J, Ait-Ghezala G, Reed J, Montague H, Chaytow H, Mathura V, Martin J, Pelot R, Ferguson S, Bishop A, Phillips J, Mullan M, Crawford F.

J Neurotrauma. 2016 Jul 15;33(14):1331-48. doi: 10.1089/neu.2015.4061. Epub 2016 Mar 9.

PMID: 26714394

 

Ultrastructural Changes in the White and Gray Matter of Mice at Chronic Time Points After Repeated Concussive Head Injury.

Ojo JO, Bachmeier C, Mouzon BC, Tzekov R, Mullan M, Davies H, Stewart MG, Crawford F.

J Neuropathol Exp Neurol. 2015 Oct;74(10):1012-35. doi: 10.1097/NEN.0000000000000247.

PMID: 26360375

 

Correction: Chronic Anatabine Treatment Reduces Alzheimer’s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.

Verma M, Beaulieu-Abdelahad D, Ait-Ghezala G, Li R, Crawford F, Mullan M, Paris D.

PLoS One. 2015 Jul 31;10(7):e0134776. doi: 10.1371/journal.pone.0134776. eCollection 2015.

PMID: 26230317

 

Chronic Anatabine Treatment Reduces Alzheimer’s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.

Verma M, Beaulieu-Abdelahad D, Ait-Ghezala G, Li R, Crawford F, Mullan M, Paris D.

PLoS One. 2015 May 26;10(5):e0128224. doi: 10.1371/journal.pone.0128224. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0134776.

PMID: 26010758

 

Gulf War agent exposure causes impairment of long-term memory formation and neuropathological changes in a mouse model of Gulf War Illness.

Zakirova Z, Tweed M, Crynen G, Reed J, Abdullah L, Nissanka N, Mullan M, Mullan MJ, Mathura V, Crawford F, Ait-Ghezala G.

PLoS One. 2015 Mar 18;10(3):e0119579. doi: 10.1371/journal.pone.0119579. eCollection 2015.

PMID: 25785457

 

The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.

Paris D, Ait-Ghezala G, Bachmeier C, Laco G, Beaulieu-Abdelahad D, Lin Y, Jin C, Crawford F, Mullan M.

J Biol Chem. 2014 Dec 5;289(49):33927-44. doi: 10.1074/jbc.M114.608091. Epub 2014 Oct 20.

PMID: 25331948

 

NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer’s disease.

Lawlor B, Kennelly S, O’Dwyer S, Cregg F, Walsh C, Coen R, Kenny RA, Howard R, Murphy C, Adams J, Daly L, Segurado R, Gaynor S, Crawford F, Mullan M, Lucca U, Banzi R, Pasquier F, Breuilh L, Riepe M, Kalman J, Wallin A, Borjesson A, Molloy W, Tsolaki M, Olde Rikkert M.

BMJ Open. 2014 Oct 9;4(10):e006364. doi: 10.1136/bmjopen-2014-006364. Erratum in: BMJ Open. 2015;5(9):e006364.

PMID: 25300460

 

Apolipoprotein E isoform-specific effects on lipoprotein receptor processing.

Bachmeier C, Shackleton B, Ojo J, Paris D, Mullan M, Crawford F.

Neuromolecular Med. 2014 Dec;16(4):686-96.

PMID: 25015123

 

Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury.

Ojo JO, Greenberg MB, Leary P, Mouzon B, Bachmeier C, Mullan M, Diamond DM, Crawford F.

Front Behav Neurosci. 2014 Jun 23;8:213. doi: 10.3389/fnbeh.2014.00213. eCollection 2014.

PMID: 25002839

 

Repetitive mild traumatic brain injury causes optic nerve and retinal damage in a mouse model.

Tzekov R, Quezada A, Gautier M, Biggins D, Frances C, Mouzon B, Jamison J, Mullan M, Crawford F.

J Neuropathol Exp Neurol. 2014 Apr;73(4):345-61. doi: 10.1097/NEN.0000000000000059.

PMID: 24607965

 

Vision function abnormalities in Alzheimer disease.

Tzekov R, Mullan M.

Surv Ophthalmol. 2014 Jul-Aug;59(4):414-33. doi: 10.1016/j.survophthal.2013.10.002. Epub 2013 Oct 22. Review.

PMID: 24309127

 

Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model.

Mouzon BC, Bachmeier C, Ferro A, Ojo JO, Crynen G, Acker CM, Davies P, Mullan M, Stewart W, Crawford F.

Ann Neurol. 2014 Feb;75(2):241-54. doi: 10.1002/ana.24064. Epub 2014 Feb 20.

PMID: 24243523

 

Chronic elevation of phosphocholine containing lipids in mice exposed to Gulf War agents pyridostigmine bromide and permethrin.

Abdullah L, Evans JE, Montague H, Reed JM, Moser A, Crynen G, Gonzalez A, Zakirova Z, Ross I, Mullan C, Mullan M, Ait-Ghezala G, Crawford F.

Neurotoxicol Teratol. 2013 Nov-Dec;40:74-84. doi: 10.1016/j.ntt.2013.10.002. Epub 2013 Oct 17.

PMID: 24140745

 

Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure.

Ojo JO, Abdullah L, Evans J, Reed JM, Montague H, Mullan MJ, Crawford FC.

Neuropathology. 2014 Apr;34(2):109-27. doi: 10.1111/neup.12061. Epub 2013 Sep 30.

PMID: 24118348

 

Effect of venlafaxine and desvenlafaxine on drug efflux protein expression and biodistribution in vivo.

Bachmeier C, Levin GM, Beaulieu-Abdelahad D, Reed J, Mullan M.

J Pharm Sci. 2013 Oct;102(10):3838-43. doi: 10.1002/jps.23680. Epub 2013 Jul 29.

PMID: 23897419

 

Role of the cannabinoid system in the transit of beta-amyloid across the blood-brain barrier.

Bachmeier C, Beaulieu-Abdelahad D, Mullan M, Paris D.

Mol Cell Neurosci. 2013 Sep;56:255-62. doi: 10.1016/j.mcn.2013.06.004. Epub 2013 Jul 3.

PMID: 23831388

 

Results of a follow-up study to the randomized Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT).

Alzheimer’s Disease Anti-inflammatory Prevention Trial Research Group..

Alzheimers Dement. 2013 Nov;9(6):714-23. doi: 10.1016/j.jalz.2012.11.012. Epub 2013 Apr 3.

PMID: 23562431

 

Amelioration of experimental autoimmune encephalomyelitis by anatabine.

Paris D, Beaulieu-Abdelahad D, Mullan M, Ait-Ghezala G, Mathura V, Bachmeier C, Crawford F, Mullan MJ.

PLoS One. 2013;8(1):e55392. doi: 10.1371/journal.pone.0055392. Epub 2013 Jan 30.

PMID: 23383175

 

Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice.

Ojo JO, Mouzon B, Greenberg MB, Bachmeier C, Mullan M, Crawford F.

J Neuropathol Exp Neurol. 2013 Feb;72(2):137-51. doi: 10.1097/NEN.0b013e3182814cdf.

PMID: 23334597

 

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.

Paris D, Beaulieu-Abdelahad D, Abdullah L, Bachmeier C, Ait-Ghezala G, Reed J, Verma M, Crawford F, Mullan M.

Eur J Pharmacol. 2013 Jan 5;698(1-3):145-53. doi: 10.1016/j.ejphar.2012.11.017. Epub 2012 Nov 21.

PMID: 23178521

 

Plasma microRNA biomarkers for detection of mild cognitive impairment.

Sheinerman KS, Tsivinsky VG, Crawford F, Mullan MJ, Abdullah L, Umansky SR.

Aging (Albany NY). 2012 Sep;4(9):590-605.

PMID: 23001356

 

Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes.

Mouzon B, Chaytow H, Crynen G, Bachmeier C, Stewart J, Mullan M, Stewart W, Crawford F.

J Neurotrauma. 2012 Dec 10;29(18):2761-73. doi: 10.1089/neu.2012.2498. Epub 2012 Nov 23.

PMID: 22900595

 

Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier.

Bachmeier C, Beaulieu-Abdelahad D, Crawford F, Mullan M, Paris D.

J Mol Neurosci. 2013 Feb;49(2):270-6. doi: 10.1007/s12031-012-9866-6. Epub 2012 Aug 14.

PMID: 22890420

 

Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents.

Abdullah L, Evans JE, Bishop A, Reed JM, Crynen G, Phillips J, Pelot R, Mullan MA, Ferro A, Mullan CM, Mullan MJ, Ait-Ghezala G, Crawford FC.

Neuromolecular Med. 2012 Dec;14(4):349-61. doi: 10.1007/s12017-012-8192-z. Epub 2012 Jul 14.

PMID: 22798222

 

A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier.

Bachmeier C, Paris D, Beaulieu-Abdelahad D, Mouzon B, Mullan M, Crawford F.

Neurodegener Dis. 2013;11(1):13-21. Epub 2012 May 8.

PMID: 22572854

 

Proteomic CNS profile of delayed cognitive impairment in mice exposed to Gulf War agents.

Abdullah L, Crynen G, Reed J, Bishop A, Phillips J, Ferguson S, Mouzon B, Mullan M, Mathura V, Mullan M, Ait-Ghezala G, Crawford F.

Neuromolecular Med. 2011 Dec;13(4):275-88. doi: 10.1007/s12017-011-8160-z. Epub 2011 Oct 11.

PMID: 21986894

 

Anatabine lowers Alzheimer’s Aβ production in vitro and in vivo.

Paris D, Beaulieu-Abdelahad D, Bachmeier C, Reed J, Ait-Ghezala G, Bishop A, Chao J, Mathura V, Crawford F, Mullan M.

Eur J Pharmacol. 2011 Nov 30;670(2-3):384-91. doi: 10.1016/j.ejphar.2011.09.019. Epub 2011 Sep 19.

PMID: 21958873

 

Demonstration of safety in Alzheimer’s patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study.

Kennelly SP, Abdullah L, Paris D, Parish J, Mathura V, Mullan M, Crawford F, Lawlor BA, Kenny RA.

Int J Geriatr Psychiatry. 2011 Oct;26(10):1038-45. doi: 10.1002/gps.2638. Epub 2010 Oct 29.

PMID: 21905098

 

Identification of plasma biomarkers of TBI outcome using proteomic approaches in an APOE mouse model.

Crawford F, Crynen G, Reed J, Mouzon B, Bishop A, Katz B, Ferguson S, Phillips J, Ganapathi V, Mathura V, Roses A, Mullan M.

J Neurotrauma. 2012 Jan 20;29(2):246-60. doi: 10.1089/neu.2011.1789. Epub 2011 Dec 7.

PMID: 21895520

 

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial.

Breitner JC, Baker LD, Montine TJ, Meinert CL, Lyketsos CG, Ashe KH, Brandt J, Craft S, Evans DE, Green RC, Ismail MS, Martin BK, Mullan MJ, Sabbagh M, Tariot PN; ADAPT Research Group..

Alzheimers Dement. 2011 Jul;7(4):402-11. doi: 10.1016/j.jalz.2010.12.014.

PMID: 21784351

 

Flavonoids lower Alzheimer’s Aβ production via an NFκB dependent mechanism.

Paris D, Mathura V, Ait-Ghezala G, Beaulieu-Abdelahad D, Patel N, Bachmeier C, Mullan M.

Bioinformation. 2011;6(6):229-36. Epub 2011 Jun 6.

Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid.

Luis CA, Abdullah L, Ait-Ghezala G, Mouzon B, Keegan AP, Crawford F, Mullan M.

Int J Alzheimers Dis. 2011;2011:786264. doi: 10.4061/2011/786264. Epub 2011 May 24.

PMID: 21660215

 

Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer’s patients–an open-label trial.

Kennelly S, Abdullah L, Kenny RA, Mathura V, Luis CA, Mouzon B, Crawford F, Mullan M, Lawlor B.

Int J Geriatr Psychiatry. 2012 Apr;27(4):415-22. doi: 10.1002/gps.2735. Epub 2011 May 10.

PMID: 21560164

 

Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer’s Disease Anti-inflammatory Prevention Trial.

Leoutsakos JM, Muthen BO, Breitner JC, Lyketsos CG; ADAPT Research Team..

Int J Geriatr Psychiatry. 2012 Apr;27(4):364-74. doi: 10.1002/gps.2723. Epub 2011 May 10.

PMID: 21560159

 

Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier.

Bachmeier C, Beaulieu-Abdelahad D, Mullan M, Paris D.

Eur J Pharmacol. 2011 Jun 1;659(2-3):124-9. doi: 10.1016/j.ejphar.2011.03.048. Epub 2011 Apr 9.

PMID: 21497592