Antidepressant May Slow Progression of Alzheimer’s Disease

According to research by the Washington University School of Medicine, published in Science Translational Medicine, a common antidepressant can reduce the production of brain plaques. Brain plaques correlate closely with memory problems and other cognitive impairments caused by Alzheimer’s disease.  Stopping plaque buildup is believed to help halt the mental decline of Alzheimer’s patients.  Scientists […]

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Event: Journal Club “The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease”

Nowell (Jim) Ganey will be presenting the paper on Friday (6/25/2010) at Roskamp Institute. Title:The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease. Journal : Biomaterials. 2010 Jul;31(21):5608-18. Epub 2010 Apr 28. Journal Club is held every Friday between 4 Pm-5pm. For change in […]

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Event Journal Club:Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice by Rhein et al. Alex Bishop will be presenting the paper on Friday (6/11/2010) at Roskamp Institute. Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter account or facebook page. The Roskamp […]

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Journal Club: The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

JC Nowell Ganey will present “The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia” on Thursday (29th April 2010) at 4:00pm in Roskamp Institute. You can find the article in the following link. The Roskamp Institute provides a full range of services for individuals with Alzheimer’s disease including diagnostic work-up […]

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Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer’s disease

Daniel Paris email, Nowell J Ganey email, Vincent Laporte email, Nikunj S Patel email, David Beaulieu-Abdelahad email, Corbin Bachmeier email, Amelia March email, Ghania Ait-Ghezala email and Michael J Mullan email The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA author email corresponding author email Journal of Neuroinflammation 2010, 7:17doi:10.1186/1742-2094-7-17 Published: 8 March 2010 […]

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CD40L induces Abeta production via signaling by the granulocyte macrophage colony stimulating factor (GM-CSF)

Alzheimer’s disease (AD) is the most common type of dementia in the elderly. AD is mainly characterized by the accumulation of a small molecule (known as amyloid beta (Abeta)) in the brain. Many researchers have shown that the molecule CD40L is elevated in AD patients. Roskamp Institute research group headed by Dr. Michael Mullan also […]

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